Internal Med Medical News about women with osteoporosis;monthly or weekly oral bisphosphonates

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Adherence to monthly and weekly oral bisphosphonates in women with osteoporosis
Osteoporosis International, 05/27/09

Cotte FE et al. - Adherence to bisphosphonates may be superior for monthly treatment than for weekly treatment and may thus provide improved fracture protection.

Methods

Study to evaluate whether monthly bisphosphonate treatment provided superior adherence than weekly treatment.
Medical claims from a national prescription database was analysed
All women aged >45 yrs receiving a first prescription of monthly ibandronate or weekly bisphosphonates in 2007 were included
Treatment adherence was monitored from initial prescription until Jan 2008
Compliance: measured by medication possession ratio (MPR)
Persistence: by the time from treatment initiation to discontinuation
Multivariate analysis used to identify variables independently associated with adherence

Results

12-mo persistence rates were 47.5% for monthly ibandronate and 30.4% for weekly bisphosphonates
Compliance was significantly higher in the monthly cohort than in the weekly cohort
Women with monthly regimens were 37% less likely to be non-persistent and presented a 5% higher mean MPR than women with weekly regimens
Other major factors associated with improved adherence: previous densitometry and calcium or vit D supplementation

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