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Medication adherence for children and adolescents with first-episode psychosis following hospitalization
European Child and Adolescent Psychiatry, 04/29/09
Gearing RE et al. - Children and adolescents discharged from their first hospitalization following a psychotic episode may be more likely to stay on prescribed antipsychotic medication if they are prescribed concurrent medication for affective symptoms.
Methods- Sixty-five children and adolescents, age 15.35 ± 2.08 years, 59% boys, who had participated in a longitudinal cohort study examining relapse following first hospitalization for episode of psychosis were included in this study.
- All those studied were discharged on one of three atypical antipsychotics, risperidone, quetiapine, or olanzapine between January 1999 and October 2003.
- Time 1 data were collected retrospectively from medical charts using a standardized questionnaire; time 2 data were obtained using questionnaire mailed to participants’ parents a minimum of 2 years post-discharge, mean 3.9 ± 1.3 years.
- Variables examined as predictors of adherence fell into broad categories of biological, social and treatment variables.
- Discharge on concurrent pharmacologic agent for affective symptoms in addition to atypical antipsychotic, OR = 10.5 [95% confidence interval (CI) = 2.06–53.19] was a strong predictor of medication adherence in adolescents.
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