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Modified Atkins diet to children and adolescents with medical intractable epilepsy
Seizure - European Journal of Epilepsy, 04/10/09

Weber S et al. - In a study to evaluate the tolerability and efficacy of the modified Atkins diet given to children and adolescents with antiepileptic drug (AED) treatment-resistant epilepsy, the present study confirms the high tolerability and effect of the modified Atkins diet on seizure control in AED treatment-resistant epilepsy.

Methods

15 children with medically intractable epilepsy were enrolled in the study.
Inclusion criteria were at least 1 seizure/week and a trial of at least 2 AEDs without obtaining seizure freedom documented in a seizure calendar.
At baseline, subjects initiated a diet with carbohydrates restricted to make up 10 energy percent.
If seizures were reduced by <50% after 7–14 days, carbohydrates were further restricted to 10 g per day.
No change in AED treatment was allowed.

Results

Diet was well tolerated.
After 3 mos, 6 of the 15 children (40%) had a seizure reduction of >50%, which was seen in different epileptic syndromes and different age groups.
Responders reported an increase in quality of life and cognition.
At 12 mos follow-up, 3 (20%) continued the diet with an unchanged marked seizure reduction.

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