Nair K et al. - Ventricular fibrillation usually is sustained and unrelenting in human subjects and rarely is self-terminating after 30 seconds' duration. Interaction of organization with high catecholamine levels and hyperkalemia may play a role in self-termination of ventricular fibrillation. Understanding the true mechanisms of spontaneous defibrillation may provide newer therapeutic options for treatment of this otherwise fatal arrhythmia.