Kharidia J et al. - In this study, plasma exposure to (R,R)-formoterol was similar for nebulized 15 mug arformoterol and 12 mug racemic formoterol DPI, and 40% lower than 24 mug racemic formoterol DPI. There was no evidence of chiral interconversion following treatment with arformoterol. Finally, temporal changes in airway function in all treatment groups corresponded to changes in (R,R)-formoterol plasma concentrations.
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