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Noncytotoxic Clostridium perfringens Enterotoxin (CPE) Variants Localize CPE Intestinal Binding and Demonstrate a Relationship between CPE-Induced Cytotoxicity and Enterotoxicity
Infection and Immunity, 07/24/08

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Smedley JG et al. - Cytotoxicity being necessary for CPE-induced enterotoxicity, the CPE sensitivity of villus tips being at least partially attributable to the abundant presence of receptors in this villus region, and claudin-4 being an important intestinal receptor for CPE.

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