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Increased Dietary NaCl induces Renal Medullary PGE2 Production and Natriuresis via the EP2 Receptor
American Journal of Physiology: Renal Physiology, 07/21/08

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Chen J et al. - High salt diet increases renal medullary COX2, mPGES1 expression and increases renal medullary PGE2 synthesis. Renal medullary PGE2 promotes renal sodium excretion via the EP2 receptor, thereby maintaining normotension in the setting of high salt intake.

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