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Dominant negative mutant Cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat
BMC Microbiology, 07/14/08

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Jadlowsky JK et al. - The results suggest that CycT1-U7 inhibits HIV transcription by promoting a rapid degradation of Tat. These mutant CycT1 proteins represent a novel class of specific inhibitors for HIV transcription that could be potentially used in the design of anti-viral therapy.

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