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Phosphodiesterase inhibitors for the treatment of pulmonary hypertension
European Respiratory Journal , 07/03/08
Print     Email This Article     Save in My Library   Free Abstract
Wilkins MR et al. - The cGMP signalling pathway for the treatment of pulmonary arterial hypertension (PAH), inhibition of cGMP metabolism by phosphodiesterase type 5 (PDE5)-targeted compounds has proven most successful to date. One PDE5 inhibitor, sildenafil, has been shown to improve pulmonary haemodynamics and exercise capacity in patients with PAH and is now an approved treatment.
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