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Severe and moderate hemophilia A: identification of 38 new genetic alterations
Haematologica, 07/02/08

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Casana P et al. - The cumulative inhibitor incidence was 22%. Approximately half the families carry non-recurrent mutations, which were unique in around one third. Harmful effects for mutations predicting null alleles are expected. Missense mutation consequences are not easily predictable, despite the help of some bio-informatics tools.

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