Iranzoa V et al. - The induction chemotherapy CT followed by concomitant chemoradiation used in this study appears feasible, safe and effective when administered to an unselected inoperable NSCLC stage III patient cohort in the everyday routine clinical practice. Methods
An induction CT scheme with carboplatin plus paclitaxel followed by RT and concomitant CT is described
31 pts with non-operable stage IIIA or IIIB NSCLC w/o pleural effusion were included in this study
30 males, 1 female; median age 66 yrs; 32% with non-operable stage IIIA and 68% with stage IIIB w/o pleural effusion; 61% SCC; 32% adenocarcinoma and 7% other histologies
Regarding performance status (PS): 9.7% PS 0 and 90% PS 1 were included
Pts received 3 courses of induction CT with carboplatin AUC=6 and paclitaxel 175 mg/m2, administrated i.v. on day 1 of each 21-day cycle
This was followed by thoracic irradiation with two concurrent courses of carboplatin/paclitaxel
Results
16.2% of the pts achieved CR, 48.4% PR, 25.8% SD and 9.6% progression of disease
Median PFS and OS was 12 and 18 mos, respectively
Most frequent haematological toxicities were grade (G) 3 anaemia in 19.3%, G3 neutropenia in 9.6% and G4 neutropenia in 12.9%
Esophageal G2 toxicity (RTOG) was observed in 28.1% of cases
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