Ninomiyaa H et al. - Characteristic histological features, i.e. the hobnail cell morphology and the presence of BAC component and MPP are good predictors of EGFR mutations in lung adenocarcinoma. Methods
Aim was to clarify links between EGFR mutations and pathological findings in Japanese lung cancer
Detailed pathological features of adenocarcinomas were examined using the WHO criteria as well as cell type classification
Medical records were reviewed for a total of 107 surgically resected tumors
Clinicopathological factors were examined and correlations with EGFR status were evaluated
EGFR mutations were found in 59% of pts distributed through all 4 exons examined
Results
EGFR mutations were associated with female gender, non-smoker status and hobnail cell morphology
In addition, detailed pathological examination showed an associations with bronchioloalveolar carcinoma (BAC) component and a micropapillary pattern
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