Halyard MY et al. - Many clinicians lack familiarity with the clinical utility of QOL measurement in clinical practice. QOL data can be a useful predictor of patient response to treatment and survival and can affect decision-making about therapeutic options. Several randomized trials have shown the feasibility and benefits of QOL assessment in the clinical setting. Issues related to QOL data collection exist for those attempting to use QOL instruments within their practice. This review addresses the questions frequently asked by oncology care providers about the value of QOL assessment and issues related to it.