Keiji O et al. - The results presented in this study suggest that the eradication of Helicobacter pylori infection reduces the incidence of gastric cancer. Methods
Association between chronic H. pylori infection and development of gastric cancer is well established
Aim was to determine whether the eradication of H. pylori infection would reduce the incidence of gastric cancer
In total, 304 pts with persistent H. pylori infection and 404 pts with H. pylori infection eradicated were examined annually for gastric cancer by endoscopy
Results
Over an average of 3.1 y and 3.2 y, 13 and 6 pts, were diagnosed as having new gastric cancer in the two groups respectively
The cumulative incidence of gastric cancer was different between the groups
The hazard ratio of H. pylori eradication was 0.335 by Cox proportional hazards model
Differentiated gastric cancer was found in 11 pts in the persistent infection group and 3 pts in the eradicated group
The incidence of differentiated cancer was significantly different between the groups, but not for undifferentiated cancer
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