Miyazaki H et al. - The aim of the present study is to investigate whether the chloride affects cell growth and cell-cycle progression of cancer cells. In human gastric cancer MKN28 cells, the culture in the Cl-replaced medium (replacement of Cl- by NO3-) decreased the intracellular chloride concentration ([Cl-]i) and inhibited cell growth. The inhibition of cell growth was due to cell-cycle arrest at the G0/G1 phase caused by diminution of CDK2 and phosphorylated Rb
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