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Soonthornpun, S., et al. - Conclusion: Although the change in Hcy levels during hyperinsulinemia was correlated with insulin sensitivity, the Hcy levels per se were not found to be correlated with insulin sensitivity. The change in Hcy levels during hyperinsulinemia was significantly different in subjects whose ISI was above and below the mean value but not in subjects with normal and abnormal glucose tolerance. This indicated that insulin resistance, not the glucose tolerance status, affected Hcy metabolism


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