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Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
Arthritis & Rheumatism, 10/27/06
R. N. Maini, et al. - To establish the safety and efficacy of repeat infusions of tocilizumab (previously known as MRA), a humanized anti-interleukin-6 (IL-6) receptor antibody, alone and in combination with methotrexate (MTX), for the treatment of rheumatoid arthritis (RA)...Conclusion: These results indicate that targeted blockade of IL-6 signaling is a highly efficacious and promising means of decreasing disease activity in RA
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Today in Clinical Pharmacology...keeping you current
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Linezolid in the Treatment of Multidrug-Resistant Tuberculosis
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Today in Rheumatology...keeping you current
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Site of psoriasis (scalp or intergluteal/perianal), >=3 affected sites, and nail dystrophy predicted psoriatic arthritis in incident psoriasis
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Both weight-bearing and non-weight-bearing exercise improved function in patients with knee osteoarthritis
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MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study
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