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See Latest ArticlesMll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations
Journal of Clinical Investigation, 10/04/06
Adrienne M. Dorrance, et al. - We previously identified a rearrangement of mixed-lineage leukemia (MLL) gene (also known as ALL-1, HRX, and HTRX1), consisting of an in-frame partial tandem duplication (PTD) of exons 5 through 11 in the absence of a partner gene, occurring in approximately 4%–7% of patients with acute myeloid leukemia (AML) and normal cytogenetics, and associated with a poor prognosis
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Tightly-wound miniknot vectors for gene therapy: A potential improvement over supercoiled minicircle DNA
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