Conventional lipid profile and lipoprotein(a) concentrations in treated patients with rheumatoid arthritis
García-gómez C et al. - Rheumatoid arthritis (RA) patients undergoing antirheumatic therapy display a nonatherogenic conventional lipid profile (high HDL-c, low apolipoprotein B concns, and low apolipoprotein B/apolipoprotein A-I ratio). This may be counteracted by the high prevalence of hyperlipoproteinemia(a) observed in these pts. Methods- An evaluation of conventional lipid risk factors and lipoprotein(a) in treated RA pts
- 122 pts; lipid profiles of pts were compared with a control group, matched for sex, age, menopausal status, and BMI
- Excess lipoprotein(a) was defined by a serum concn >0.3 g/l
Results- High-density lipoprotein cholesterol (HDL-c) concns were higher in pre- and postmenopausal women with RA vs controls
- All RA pts had lower levels of apolipoprotein B and apolipoprotein B/apolipoprotein A-I ratio
- Postmenopausal women with RA also had lower low-density lipoprotein cholesterol and total cholesterol levels vs controls
- No differences observed in serum levels of apolipoprotein A-I and triglyceride
- All RA pts had higher lipoprotein(a) values than controls
- 56% men and 53% and 54% pre- and postmenopausal women with RA, respectively, had hyperlipoproteinemia(a)
[more...]
|
|
|
