Adenomatous human parathyroid cells exhibit impaired sensitivity to L-amino acids Conigrave AD et al. - Impaired L-amino acid sensing by calcium-sensing receptors in adenomatous parathyroid cells contributes to the loss of feedback control of PTH secretion in primary hyperparathyroidism. The CaR's amino acid binding site may be exploited as a target in the medical treatment of primary and perhaps other forms of hyperparathyroidism. [more...]
