Differences in long-term disease activity and treatment of adult patients with childhood- and adult-onset systemic lupus erythematosus
Hersh AO et al. – Study demonstrates important differences in the outcomes of patients with childhood systemic lupus erythematosus (cSLE) and adult SLE (aSLE), and provides important prognostic information about long-term SLE disease activity and treatment. Methods- Aim was to compare differences in long-term outcome cSLE and aSLE
- Data derived from a cohort of 885 adult subjects with SLE (90 cSLE, 795 aSLE)
- Baseline and 1-yr f/u data obtained via structured 1-hr telephone interviews
- Differences in organ involvement and disease morbidity, current disease status and activity, past and current medication use, and number of physician visits were compared
Results- Average disease duration for cSLE and aSLE subgroups was 16.5 and 13.4 yrs, respectively
- Mean age at f/u was 30.5 and 49.9 yrs, respectively
- cSLE subjects had a higher frequency of SLE-related renal disease, whereas aSLE subjects were more likely to report a history of pulmonary disease
- Rates of clotting disorders, seizures, and myocardial infarction were similar between the 2 groups
- At f/u, cSLE subjects had lower overall disease activity, but were more likely to be taking steroids and other immunosuppressive therapies
- Total number of yearly physician visits was similar between the 2 groups, although cSLE subjects had a higher number of nephrology visits
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