Omission of concurrent chemoradiation after a response to neoadjuvant chemotherapy in locally advanced rectal cancer with a synchronous liver metastasis
Craven, I., et al. - A case study that illustrates the potential risk of omitting radiation following a good response to neoadjuvant systemic chemotherapy in locally advanced rectal cancer with a synchronous liver metastasis.
Methods
- An overview of potential risk of omitting radiation following a good response to neoadjuvant systemic chemotherapy
Results
- There is clear evidence to support the use of pre-operative concurrent chemo-radiotherapy (CRT) in locally advanced rectal cancer
- In the UK, most pts are selected for treatment if the resection margin is predicted to be involved
- The selection criteria used includes primary tumours that threaten the resection margins on high-resolution pelvic MRI and low tumours requiring abdominoperineal excision
- There is no consensus, however, to guide the treatment of pts who present with advanced rectal disease and synchronous, potentially resectable, metastatic disease
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