Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase Shotaro Iwamoto, et al. - Because of their low asparagine synthetase (ASNS) expression and asparagine biosynthesis, acute lymphoblastic leukemia (ALL) cells are exquisitely sensitive to asparagine depletion. Consequently, asparaginase is a major component of ALL therapy, but the mechanisms regulating the susceptibility of leukemic cells to this agent are unclear [more...]
