Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women
Corbould, A., - Do androgens influence insulin-mediated glucose metabolism in adipose cells?
>Summary: Preadipocytes harvested from s.c. adipose tissue of healthy women were differentiated in vitro, then treated with testosterone (T) and/or androgen receptor (AR) antagonists (cyproterone acetate, flutamide) for 48 hours. Maximal insulin-stimulated glucose uptake (insulin 10 nM) and increment following insulin stimulation were significantly impaired in cells treated with T 10 and 100 nmol/l.
Outcomes: The findings of this study are relevant to understanding the pathogenesis of insulin resistance in hyperandrogenic women [more...]
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