Prediction of Diabetic Nephropathy Using Urine Proteomic Profiling 10 Years Prior to Development of Nephropathy
Hasan H. Otu, PHD., et al. – Is proteomic profiling valuable in identifying progression of diabetic nephropathy?
>Summary: In a nested case-control study of Pima Indians with type 2 diabetes, baseline and 10-year urine samples were examined. Thirty one case subjects developed diabetic nephropathy over 10 years. The same number of control subjects were matched to case subjects according to diabetes duration, age, sex, and BMI but remained normoalbuminuric over the same 10 years. The study examined whether proteomic technologies could identify novel urine proteins associated with subsequent development of diabetic nephropathy.
Outcomes: Urine proteomic profiling identifies normoalbuminuric subjects with type 2 diabetes who subsequently develop diabetic nephropathy. Further studies are needed to characterize the specific proteins involved in this early prediction [more...]
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