Top renal cell Articles in Internal Medicine

Effect of Collecting Duct Histology on Renal Cell Cancer Outcome
The Journal of Urology, 11/18/2009

Wright JL et al. – Compared to patients with clear cell renal cell carcinoma those with collecting duct renal cell carcinoma have higher stage and are more often black. Even after adjusting for demographic, surgical and ... is significantly worse in patients with collecting duct rather than clear cell renal cell carcinoma. [more...]

Chromosomal abnormalities of clear cell renal cell carcinoma: Frequent gain of chromosome 7
Pathology International, 11/19/2009

Kuroda N et al. – The present study shows that gain of chromosome 7 is not exclusive to papillary RCC, but it can be found in clear cell RCC as well, and this finding may represent a diagnostic pitfall in distinguishing clear cell RCC ... from papillary RCC. [more...]

Prognostic Value of Capsular Invasion for Localized Clear-Cell Renal Cell Carcinoma
European Urology, 11/10/2009

Cho HJ et al. – Capsular invasion in clear–cell renal cell carcinoma is associated with specific clinicopathologic findings and has an impact on prognosis in localized tumors. [more...]

Simultaneous Infiltration of Polyfunctional Effector and Suppressor T Cells into Renal Cell Carcinomas
Cancer Research, 11/03/2009

Attig S et al. – Compared with the same patient's peripheral blood, T lymphocytes present inside tumors were found to be enriched in functional CD4+ cells of the Th1 lineage and in effector memory CD8+ cells. Additionally, several ... regulatory T cells were identified that may synergize to locally dampen antitumor T–cell responses. [more...]

Strong expression of chemokine receptor CXCR4 by renal cell carcinoma cells correlates with metastasis
Clinical and Experimental Metastasis, 11/02/2009

Wang L et al. – Renal cell carcinoma metastasis was associated with higher expression of CXCR4 and interaction of CXCR4 and its ligand CXCL12 resulted in the internalization of CXCR4 from ... the CXCR4–CXCL12 axis in the metastasis of renal cell carcinoma. [more...]

Multipotent mesenchymal stromal cell therapy in renal disease and kidney transplantation
Nephrology Dialysis Transplantation, 11/05/2009

Reinders MEJ et al. – Multipotent mesenchymal stromal cells (MSCs), often referred to as mesenchymal stem cells, are of particular interest as a cell therapy model, as this is one of the few cell types that are on ... different areas of application. Evidence for the renoprotective mechanisms of MSCs as well as their therapeutic possibilities and potential hazards in acute and chronic renal disease and allograft rejection is summarized. [more...]

Expression Profile of the Polycomb Group Protein Enhancer of Zeste Homologue 2 and its Prognostic Relevance in Renal Cell Carcinoma
The Journal of Urology, 11/23/2009

Hinz S et al. – These data support a role of EZH2 expression for renal cell carcinoma tumorigenesis rather than tumor progression. The findings suggest that EZH2 provides not only ... patients with renal cell carcinoma. [more...]

Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma
British Journal of Cancer, 11/20/2009

Bilim V et al. – The results show nuclear accumulation of GSK–3beta as a new marker of human RCC, identify that GSK–3 positively regulates RCC cell survival and proliferation and suggest inhibition of ... of human renal cancer. [more...]

Renal Cell Carcinoma in Association With IgA Nephropathy in the Elderly
The American Journal of the Medical Sciences, 11/13/2009

Mimura I et al. – The authors report 3 cases of IgA nephropathy associated with renal cell carcinoma in the elderly patients and demonstrate that infiltrating lymphocytes and plasma cells around renal cell carcinoma [more...]

Where does the combination of sorafenib and interferon in renal cell carcinoma stand
Cancer, 11/12/2009

Flaherty KT – Sorafenib can be combined safely with interferon, but the results of a recent randomized, phase 2 trial cast doubt on the value of further evaluating this combination. The renal cell carcinoma field continues to wrestle ... targeted" therapies with cytokines. [more...]