Top hypertension Articles in Internal Medicine

Effective strategies for management of hypertension after vascular endothelial growth factor signaling inhibition therapy: Results from a phase II randomized, factorial, double-blind study of cediranib in patients with advanced solid tumors
Journal of Clinical Oncology, 11/13/2009

Langenberg MHG et al. – All four regimens were well ... The current cediranib hypertension management protocol appears to be effective in managing hypertension compared with previous cediranib studies where no plan was in place, and early recognition and treatment of hypertension is likely to reduce the number of severe hypertension events. This protocol ... cediranib 30 or 45 mg/d with or without antihypertensive prophylaxis All patients developing hypertension on cediranib treatment treated with standardized, predefined hypertension management protocol Results Cediranib generally well tolerated, and all groups ... or interruptions Increases in blood pressure, including moderate and severe readings of hypertension, seen early in treatment in all groups and successfully managed Severe hypertension occurred in 1 patient receiving prophylaxis versus 18 in nonprophylaxis groups 9 partial [more...]

Lessons in Hypertension from New Clinical Trials
Postgraduate Medicine, 11/24/2009

Nesbitt SD – Three important principles have emerged from recent epidemiologic and clinical studies in hypertension. First, patients with hypertension most often have other cardiovascular risk factors such as obesity and diabetes. Second, hypertension ... agents available to treat hypertension, blockers of the renin–angiotensin system are effective in type 2 diabetes and chronic kidney disease, conditions that often occur in conjunction with hypertension. [more...]

The Role of Renal Sympathetic Nerves in Hypertension: Has Percutaneous Renal Denervation Refocused Attention on Their Clinical Significance
Progress in Cardiovascular Diseases, 11/30/2009

Katholi RE et al. – Because the causative factors of hypertension change over time, denervation of both efferent and afferent nerves should result in ... hypertension. The importance of the renal nerves in patients with hypertension can now be defined with the novel development of percutaneous minimally invasive renal denervation from within the renal artery using radiofrequency energy as a therapeutic strategy. Studies thus far show that catheter ... ndash;based renal denervation in patients with refractory hypertension lowers systolic blood pressure 27 mm Hg by 12 months with estimated glomerular filtration rate remaining stable. An attenuation of hypertension of this magnitude by catheter–based renal sympathetic denervation in ... decreasing the risks of stroke, left ventricular hypertrophy, heart failure, and chronic renal failure. [more...]

Decrease in FASN Expression in Adipose Tissue of Hypertensive Individuals
American Journal of Hypertension, 11/23/2009

Mayas MD et al. – It has been proven, for the first time, that there is a decrease of FASN expression in hypertensive individuals. The clinical significance of this work represents an exciting challenge because it ... of FASN expression may be associated with hypertension or whether this is an adaptive mechanism to the presence of hypertension. Once this aspect is clarified, it could be a new target for the treatment of hypertension. [more...]

Decrease in FASN Expression in Adipose Tissue of Hypertensive Individuals
American Journal of Hypertension, 11/25/2009

Mayas MD et al. – In conclusion, to authors' knowledge it has been proven, for the first time, that there is a decrease of FASN expression in hypertensive individuals. The clinical significance of this work represents ... clarified whether the reduced values of FASN expression may be associated with hypertension or whether this is an adaptive mechanism to the presence of hypertension. Once this aspect is clarified, it could be a new target for the treatment of hypertension. [more...]

Aldosterone Contributes to Blood Pressure Variance and to Likelihood of Hypertension in Normal-Weight and Overweight African Americans
American Journal of Hypertension, 12/01/2009

Kidambi S et al. – PA, but not WC, is associated with BP and likelihood of hypertension in normal–weight AAs, whereas both WC and PA are predictive of hypertension in overweight and obese ... aldosterone antagonists may be useful for the treatment of hypertension among AAs, regardless of BMI. [more...]

Advancing the Prevention and Control of Hypertension
American Journal of Lifestyle Medicine, 11/16/2009

Terre L – Hypertension is on a worrisome public health trajectory. This review discusses some key contributing dynamics as well as considerations for progress toward the prevention and control of hypertension and its comorbidities. [more...]

Sex-specific hemodynamic and non-hemodynamic determinants of aortic root size in hypertensive subjects with left ventricular hypertrophy
Hypertension Research, 11/09/2009

Cipolli JAA et al. – The results suggest that both volume overload and abdominal obesity are related to AoR dilatation in hypertensive women, whereas AoR enlargement is associated more ... related parameters in hypertensive men with LV hypertrophy. [more...]

Tips to deal with hypertension
Internet Source, 11/30/2009

These days, hypertension is a very common problem. It is a lifestyle disorder – not something you are born with, but something acquired due to a faulty lifestyle. Hypertension can vary depending upon different personality types. People with a ‘pitta’ personality, for ... suffer from hypertension, are usually prone to headaches, red eyes and digestive problems. [more...]

Beta-Adrenergic Antagonists in Hypertension: A Review of the Evidence
Annals of Pharmacotherapy, 11/25/2009

Warmack TS et al. – Overall, data supporting Beta–blockers as preferred therapy in hypertension are inadequate. Although most negative cardiovascular and cerebrovascular outcomes of beta–blockers were ... supporting other beta–blockers in hypertension are lacking. [more...]