Top fibrosis Articles in Internal Medicine

Amelioration of Penile Fibrosis: Myth or Reality
Journal of Andrology, 11/25/2009

El–Sakka AI et al. – The aim of this review is to address the underlying etiology of corporal fibrosis especially, aging, cavernosal nerve damage, androgen deprivation in addition to tunical fibrosis. The authors will address the ... reversion of fibrosis in terms of correcting, at least partially, the relative SMC loss occurring with: aging, diabetes, or cavernosal nerve damage and their impact on prevention of erectile dysfunction (ED) associated–cavernosal fibrosis. [more...]

Prevalence and outcome of pulmonary fibrosis in microscopic polyangiitis
European Respiratory Journal, 11/24/2009

Tzelepis GE et al. – Pulmonary fibrosis occurs frequently in MPA, may precede other disease manifestations by a variable length of time, and has a poor prognosis. [more...]

Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis
World Journal of Gastroenterology, 11/12/2009

Kim HK et al. – The study demonstrates that green tea administration can effectively improve liver fibrosis caused by DMN, and may be used as a therapeutic option and preventive measure against hepatic fibrosis. [more...]

Diabetes as a Determinant of Mortality in Cystic Fibrosis
Diabetes Care, 11/23/2009

Chamnan P et al. – Individuals with cystic fibrosis (CF) die earlier with diabetes, which, if delayed or better treated, might reasonably extend survival, and merits testing. [more...]

Chances and limitations of non-invasive tests in the assessment of liver fibrosis in liver transplant patients
Clinical Transplantation, 11/20/2009

Kamphues C et al. – The transient elastography is a reliable test for exclusion of liver cirrhosis in HCV transplant and significant liver fibrosis in alcoholic transplant patients. For the diagnosis of significant liver fibrosis in HCV ... results but cannot replace liver biopsy. Both serum markers AST–to–platelet ratio index and FIB–4 are not feasible to assess liver fibrosis in liver transplant patients. [more...]

Smoking-related Lung Disease
Journal of Thoracic Imaging, 12/08/2009

varying combinations of emphysema, airway inflammation, and fibrosis in addition to the changes of pulmonary Langerhans' cell histiocytosis. There is also growing acceptance of a link between cigarette smoke and alveolar wall fibrosis. Acute eosinophilic pneumonia is a dramatic response to recent ... interconnected pathways that lead to lung inflammation and fibrosis in cigarette smokers are slowly coming into focus. [more...]

Connective Tissue Growth Factor-(CTGF, CCN2) - A Marker, Mediator and Therapeutic Target for Renal Fibrosis
Nephron: Experimental Nephrology, 12/03/2009

Phanish MK et al. – The authors discuss the biology of CCN2 with a focus on the regulation of CCN2 gene, cellular mechanisms of profibrotic CCN2 effects and the current in vivo and in vitro evidence for the role of CCN2 in the development of renal fibrosis. They also ... therapeutic potential of targeting CCN2 for the treatment of renal fibrosis. [more...]

Role of T Cell TGF[beta] Signaling and IL-17 in Allograft Acceptance and Fibrosis Associated with Chronic Rejection
Journal of Immunology, 12/07/2009

Faust SM et al. – In recipients transiently depleted of CD4+ T cells, T cell TGF[beta] signaling was required for the development of fibrosis associated with CR, long–term graft acceptance ... Furthermore, IL–17 was identified as a critical element in TGF[beta]–driven allograft fibrosis. Thus, IL–17 may provide a therapeutic target for preventing graft fibrosis, a measure of CR, while sparing the immunosuppressive activity of TGF[beta]. [more...]

Independent Predictors of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
Clinical Gastroenterology and Hepatology, 11/05/2009

Hossain N et al. – In patients with NAFLD, diabetes mellitus and aminotransferase levels are independent predictors of moderate–to–severe fibrosis. They can be used to identify NAFLD patients at risk for advanced fibrosis [more...]

Peripheral CXCR3-Associated Chemokines as Biomarkers of Fibrosis in Chronic Hepatitis C Virus Infection
The Journal of Infectious Diseases, 11/03/2009

Zeremski M et al. – The strong association between CXCR3–associated chemokines and fibrosis suggests that they may have promise as noninvasive markers of hepatic fibrosis in a predominantly white HCV genotype 1 [more...]