Top antiphospholipid Articles in Internal Medicine

Common infectious agents prevalence in antiphospholipid syndrome
Lupus, 11/05/2009

Zinger H et al. – This novel finding suggests that these infections might be associated with antiphospholipid syndrome. As autoimmune diseases and, in particular, antiphospholipid syndrome are associated with infections, mainly ... this finding implies that a current infection with these agents, i.e. toxoplasma and rubella, might either be related to the pathogenesis of antiphospholipid syndrome or alternatively to its manifestations. [more...]

The Cardiac Manifestations of Antiphospholipid Syndrome and Their Echocardiographic Recognition
Journal of The American Society of Echocardiography, 10/09/2009

Silbiger JJ – Antiphospholipid syndrome is an autoimmune disorder characterized by the presence of antiphospholipid antibodies, hypercoagulability, vascular thrombosis, and recurrent fetal loss ... are detected quite often echocardiographically, but hemodynamically significant stenotic and/or regurgitant valvular disease is uncommon. Antiphospholipid syndrome can also cause left and right ventricular systolic and diastolic dysfunction as well as pulmonary hypertension. [more...]

Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study
The Lancet Neurology, 10/16/2009

Urbanus RT et al. – Arterial thrombosis is a major clinical manifestation of the antiphospholipid syndrome, which is an autoimmune disease found mostly in young women. Although the ... presence of circulating antiphospholipid antibodies in individuals who have a thrombotic event is a prerequisite for the diagnosis of the antiphospholipid syndrome, the risk of arterial thrombosis associated with antiphospholipid antibodies in the general population is unclear.Our results suggest ... smoking, and hypertension) assessed with standard questionnaire During the second phase (1998—2002), blood samples taken to measure antiphospholipid antibody profiles (lupus anticoagulant, anticardiolipin IgG, anti-?2-glycoprotein I IgG, and antiprothrombin IgG) and determine genetic [more...]

Management of the antiphospholipid syndrome: new approaches
International Journal of Clinical Rheumatology, 10/19/2009

Seif AM et al. – The antiphospholipid syndrome (APS) is an autoimmune, multisystemic disorder associated with recurrent thrombosis (arterial and/or venous) and pregnancy loss, among other clinical manifestations. These new ... might be used in the future to treat clinical manifestations of this disease that are associated with devastating consequences, and are pending adequate clinical trials. [more...]

Right atrium myxoma coexisting with antiphospholipid syndrome
Cardiovascular Ultrasound, 10/12/2009

Pliakos C et al. – In this case report authors describe a rare case of right atrium myxoma that coexisted with antiphospholipid syndrome in a young woman. The authors describe the unusual findings and diagnostic challenges [more...]

Update on antiphospholipid antibodies: clinical significance
International Journal of Clinical Rheumatology, 10/19/2009

Tincani A et al. – The detection of different aPL profiles seems to increase the diagnostic specificity of the tests. The future research should focus on the development of assays that selectively identify aPL associated with ... of thrombosis or pregnancy complications, in order to lead to therapeutic strategies able to prevent unresolved problems associated with aPL. [more...]

Beta2 glycoprotein I (beta2GPI) binds platelet factor 4 (PF4): implications for the pathogenesis of antiphospholipid syndrome
Blood, 10/09/2009

Sikara MP et al. – This study makes evident that beta2GPI forms stable complexes with PF4, leading to the stabilization of beta2GPI dimeric structure which ... of APS. [more...]

Catastrophic antiphospholipid syndrome in a patient with Down syndrome
Lupus, 10/05/2009

Medina G et al. – The authors report a patient with Down syndrome, under treatment with carbamazepine, levopromazine and clonazepam. This is the first case of CAPS in a patient with Down syndrome. [more...]

Autoimmunity and Recurrent Pregnancy Losses
Clinical Reviews in Allergy and Immunology, 10/27/2009

these antibodies, vasculopathy of the terminal spiral arteries may be implicated and there is a general consensus to routinely screen for antiphospholipid antibodies in patients with recurrent miscarriage. Well–designed diagnostic studies are needed to estimate the true association between [more...]

A STAT4 risk allele is associated with ischemic cerebrovascular events and antiphospholipid antibodies in Systemic Lupus Erythematosus
Annals of Rheumatic Diseases, 10/23/2009

Svenungsson E et al. – SLE patients with the STAT4 risk allele had a strikingly increased risk of ICVD, comparable in magnitude to that of hypertension. The [more...]