U1-Small Nuclear Ribonucleoprotein Activates the NLRP3 Inflammasome in Human Monocytes

The Journal of Immunology, 05/16/2012

The findings indicate that endogenous RNA–containing U1–small nuclear ribonucleoprotein (U1–snRNP) could be a signal that activates the NOD–like receptor family, pyrin domain–containing 3 (NLRP3) inflammasome in autoimmune diseases like systemic lupus erythematosus where anti–U1–snRNP Abs are present.

Print Article Summary

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List