Phase 2 trial of irinotecan and thalidomide in adults with recurrent anaplastic glioma
Cancer,  Clinical Article

Giglio P et al. – The combination of thalidomide and irinotecan did not achieve sufficient efficacy to warrant further investigation against anaplastic gliomas (AGs), although a subset of patients experienced prolonged progression–free survival (PFS)/overall survival (OS). A trial of the more potent thalidomide analogue, lenalidomide, in combination with irinotecan against AG is currently ongoing.

Methods
  • Adults with recurrent AG previously treated with radiation therapy, with Karnofsky performance score ≥70, adequate organ function and not on enzyme-inducing anticonvulsants were enrolled.
  • Treatment was in 6-week cycles with irinotecan at 125mg/m2 weekly for 4weeks followed by 2weeks off, and thalidomide at 100mg daily increased to 400mg/day as tolerated.
  • The primary endpoint was progression-free survival rate at 6months (PFS-6), and the secondary endpoints were overall survival (OS) and response rate (RR).

Results
  • In 39 eligible patients, PFS-6 for the intent-to-treat population was 36% (95% confidence interval [CI]=21%, 53%), median PFS was 13weeks (95% CI=6%, 28%) and RR was 10%(95% CI=3%, 24%).
  • Radiological findings included 2 complete and 2 partial responses and 17 stable disease.
  • Median OS from study registration was 62weeks, (95% CI=51, 144).
  • Treatment-related toxicities (grade 3 or higher) included neutropenia, diarrhea, nausea, and fatigue; 6 patients experienced venous thromboembolism.
  • Four deaths were attributable to treatment-related toxicities: 1 from pulmonary embolism, 2 from colitis, and 1 from urosepsis.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Internal Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Internal Medicine Articles

1 Acupuncture for chronic knee pain: a randomized clinical trial JAMA, October 1, 2014    Evidence Based Medicine    Clinical Article

2 Calcium and phosphorus intake and prostate cancer risk: A 24-y follow-up study American Journal of Clinical Nutrition, November 26, 2014    Clinical Article

3 Effects of tea intake on blood pressure: A meta-analysis of 21 randomized controlled trials JACC - Journal of the American College of Cardiology, October 22, 2014    Clinical Article

4 Vitamin D and Calcium Supplementation to Prevent Fractures in Adults: U.S. Preventive Services Task Force Recommendation Statement Full Text Annals of Internal Medicine, February 26, 2013    Free full text    Clinical Guideline

5 Aggressive risk factor reduction study for atrial fibrillation and implications for the outcome of ablation: The ARREST-AF cohort study JACC - Journal of the American College of Cardiology, December 3, 2014    Evidence Based Medicine    Clinical Article

6 The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective randomized controlled trial Hepatology, December 24, 2014    Clinical Article

7 Sweetened carbonated beverage consumption and cancer risk: Meta-analysis and review European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Review Article

8 Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial The Lancet, December 11, 2014    Evidence Based Medicine    Clinical Article

9 Cytisine versus nicotine for smoking cessation New England Journal of Medicine, December 18, 2014    Evidence Based Medicine    Clinical Article

10 P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study The Lancet, December 2, 2014    Evidence Based Medicine    Clinical Article

11 Avoidance of sun exposure is a risk factor for all-cause mortality: results from the MISS cohort Journal of Internal Medicine, April 22, 2014    Evidence Based Medicine    Clinical Article

12 Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: The GIPS-III randomized clinical trial Full Text JAMA, April 16, 2014    Free full text    Evidence Based Medicine    Clinical Article

13 Tea consumption and leukemia risk: A meta-analysis Tumor Biology, February 12, 2014    Evidence Based Medicine    Clinical Article

14 Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease Clinical Nutrition, August 11, 2014    Clinical Article

15 Coffee consumption and risk of nonaggressive, aggressive and fatal prostate cancer - A dose-response meta-analysis Full Text Annals of Oncology, December 2, 2013    Free full text    Evidence Based Medicine    Clinical Article

16 Sodium zirconium cyclosilicate in hyperkalemia New England Journal of Medicine, November 26, 2014    Evidence Based Medicine    Clinical Article

17 Resveratrol levels and all-cause mortality in older community-dwelling adults JAMA Internal Medicine, May 13, 2014    Evidence Based Medicine    Clinical Article

18 Factor XI antisense oligonucleotide for prevention of venous thrombosis New England Journal of Medicine, December 10, 2014    Evidence Based Medicine    Clinical Article

19 Aspirin in type 2 diabetes, a randomised controlled study: effect of different doses on inflammation, oxidative stress, insulin resistance and endothelial function International Journal of Clinical Practice, December 27, 2013    Clinical Article

20 Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial The Lancet, December 19, 2014    Evidence Based Medicine    Clinical Article

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicinemore

 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List