Impact of Persistent HIV Replication on CD4 Negative Vγ2Vδ2 T Cells Full Text
The Journal of Infectious Diseases, 04/13/2012
Boudová S et al. – Characteristics of Vγ2Vδ2 T cells in viremic patients reflect both active responses (increasing cell numbers, better antigen responses, and higher proportion of effector memory cells) and ongoing damage (repertoire changes and loss of CD56+ cells). Unlike patients who control viremia to undetectable levels, Vγ2Vδ2 T cells are diminished during persistent viremia and may eventually be lost because of progressive destruction of the TCR repertoire.