Prevalence of vitamin D insufficiency/deficiency in rheumatoid arthritis and associations with disease severity and activity

The Journal of Rheumatology, 10/22/2010

Kerr GS et al. – The purpose of this study was to define the prevalence and associations of 25-OH-D insufficiency/deficiency in a cohort of US veterans with RA. In a predominantly elderly, male RA population, 25-OH-D insufficiency was highly prevalent. With the increasing adverse health outcomes associated with hypovitaminosis D, screening and supplementation, particularly among minority, seropositive patients with RA, should be performed routinely.

Methods

  • Vitamin D status (25-OH-D) assessed in patients with RA using radioimmunoassay on banked plasma collected at enrollment
  • Insufficiency defined as concentrations < 30 ng/ml and deficiency as < 20 ng/ml
  • Associations of 25-OH-D insufficiency/deficiency with patient characteristics obtained at enrollment examined using multivariate logistic regression, adjusting for age, sex, season of enrollment, and race

Results

  • Patients (850 men, 76% Caucasian) had mean (SD) age of 64 (SD 11.3) years
  • Prevalences of 25-OH-D insufficiency and deficiency 84% and 43%
  • After multivariate adjustment, both insufficiency and deficiency more common with anti-cyclic citrullinated peptide antibody positivity and non-Caucasian race, and in absence of vitamin D supplementation
  • 25-OH-D deficiency, but not insufficiency, independently associated with higher tender joint counts and highly sensitive CRP levels

Print Article Summary

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List