Novel Approaches to Inhibition of Gastric Acid Secretion
Current Gastroenterology Reports, 10/12/2010
Sachs G et al. – Proton pump inhibitors with a longer dwell time or P–CABs with long duration promise to address unmet clinical needs arising from an inability to inhibit nighttime acid secretion, with continued symptoms, delayed healing, and growth suppression of H. pylori reducing susceptibility to clarithromycin and amoxicillin. Thus, novel and more effective suppression of acid secretion would benefit those who suffer from acid–related morbidity, continuing esophageal damage and pain, nonsteroidal anti–inflammatory drug–induced ulcers, and nonresponders to H. pylori eradication.