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Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramine
Journal of Anesthesia, 03/15/2010
Arai Y–CP et al. – Low–dose gabapentin–imipramine significantly decreased the total pain score and daily paroxysmal pain episodes. Several patients developed mild adverse symptoms in the four groups, and three patients discontinued treatment due to severe adverse events in the G800 group. Low–dose gabapentin–antidepressant combination with opioids was effective in managing neuropathic cancer pain without severe adverse effects.
