Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterol JACC - Journal of the American College of Cardiology, 10/07/2011

Lee KH et al. – Statin therapy in patients with acute myocardial infarction (AMI) with low–density lipoprotein cholesterol (LDL–C) levels below 70 mg/dl was associated with improved clinical outcome.

• Authors analyzed 1,054 patients with AMI who had baseline LDL–C levels below 70 mg/dl and survived at discharge from the Korean Acute MI Registry between November 2005 and December 2007.
• They were divided into 2 groups according to the prescribing of statins at discharge (statin group n = 607; nonstatin group n = 447).
• The primary endpoint was the composite of 1–year major adverse cardiac events, including death, recurrent MI, target vessel revascularization, and coronary artery bypass grafting.

• Statin therapy significantly reduced the risk of the composite primary endpoint (adjusted hazard ratio [HR]: 0.56; 95% confidence interval [CI]: 0.34 to 0.89; p = 0.015).
• Statin therapy reduced the risk of cardiac death (HR: 0.47; 95% CI: 0.23 to 0.93; p = 0.031) and coronary revascularization (HR: 0.45, 95% CI: 0.24 to 0.85; p = 0.013).
• However, there were no differences in the risk of the composite of all–cause death, recurrent MI, and repeated percutaneous coronary intervention rate.