Different patterns of auditory information processing deficits in chronic schizophrenia and bipolar disorder with psychotic features
Schizophrenia Research, 06/26/2012

Domjan N et al. – The results indicate that schizophrenia and bipolar disorder–I are characterized by highly different neurophysiological profiles when measured in the same laboratory setting.

• In this study, the authors aimed at investigating the changes of five auditory event-related potentials (P50 and N100 suppression, duration and pitch deviant mismatch negativity (MMN) and P3b) in 20 SZ and 20 BD-I patients with a history of psychosis and 21 healthy control subjects.

• The data revealed substantial differences between the two patient groups.
• Only patients with SZ demonstrated impaired N100 suppression, shorter duration deviant MMN latency and attenuated P3b amplitude, while prolonged pitch deviant MMN latency was found to be characteristic of the BD-I group.
• No shared ERP abnormalities were observed among the patient groups.