High-Dose Vitamin D: Helpful or Harmful
Current Rheumatology Reports, 03/09/2011

Hansen KE – In a randomized, placebo–controlled trial, high–dose, once–yearly vitamin D therapy increased the incidence of fractures and falls. The second study reported that high–dose vitamin D did not reduce levels of parathyroid hormone or bone resorption among adults with 25(OH)D levels less than 32 ng/mL at baseline. It is time to question whether serum 25(OH)D levels of 30 ng/mL or greater are necessary for all individuals.