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Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease
Atherosclerosis, 07/18/2011
Clinical Article
Toyama K et al. – Compared to atorvastatin, rosuvastatin combined with exercise significantly preserved ubiquinol levels associated with an increase in HDL–C. Rosuvastatin with regular exercise could be beneficial for coronary artery disease (CAD) patients.
Methods- After randomizing 28 CAD patients to rosuvastatin (n=14) and atorvastatin (n=14) groups, patients performed weekly in–hospital aerobic exercise and daily home exercise for 20weeks.
- Authors measured serum lipids, ubiquinol, and exercise capacity.
- Both statins equally improved exercise capacity and lowered low–density lipoprotein cholesterol and triglyceride levels.
- Rosuvastatin significantly increased HDL–C (rosuvastatin, +12±9mg/dL [+30%], atorvastatin, +5±5mg/dL [+13%], p=0.014) and apolipoprotein A1 (ApoA1) (rosuvastatin, +28.3±20.7mg/dL, atorvastatin, +13.4±12.0mg/dL, p=0.030) compared to atorvastatin.
- Atorvastatin significantly decreased serum ubiquinol (731±238 to 547±219nmol/L, p=0.001), but rosuvastatin (680±233 to 668±299nmol/L, p=0.834) did not.
- There was a significant positive correlation between changes in ubiquinol and ApoA1 (r=0.518, p=0.005).
- Multivariate regression analysis showed that changes in ubiquinol correlated significantly with changes in ApoA1 after adjusting for age, sex, body mass index, and smoking (β=0.502, p=0.008).