Internal Medicine News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Latest (277) Full Text Articles (9654) Focus on Cancer

Ranked, sorted, and summarized by MDLinx editors from the latest literature

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1 Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterol Full Text JACC - Journal of the American College of Cardiology, October 8, 2012 Original Publication Date: October 7, 2011 Clinical Article

2 Differential Effects of Adiposity on Pharmacodynamics of Basal Insulins NPH, Glargine, and Detemir in Type 2 Diabetes Full Text Diabetes Care, October 8, 2012 Original Publication Date: October 7, 2011

3 Phase I/II and Pharmacodynamic Study of Dovitinib (TKI258)-an Inhibitor of Fibroblast Growth Factor Receptors and VEGF Receptors-in Patients with Advanced Melanoma Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 7, 2011 Clinical Article

4 Multicenter, Phase II Study of Axitinib, a Selective Second-Generation Inhibitor of Vascular Endothelial Growth Factor Receptors 1, 2, 3, in Patients with Metastatic Melanoma Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 7, 2011 Clinical Article

5 A Phase 1 dose-escalation study of the safety and pharmacokinetics of once-daily oral foretinib, a multi-kinase inhibitor, in patients with solid tumors Full Text Investigational New Drugs, October 8, 2012 Clinical Article

6 A Phase I Dose Esclation Study of Tivantinib in Adult Pts w Metastatic Solid Tumors Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 7, 2011 Clinical Article

7 Pam50 breast cancer subtyping by RT-QPCR and concordance with standard clinical molecular markers Full Text BMC Genomics, October 8, 2012

8 A prospective cohort study of health behavior profiles after age 50 and mortality risk Full Text BMC Public Health, October 8, 2012

9 Phase I and pharmacokinetic study of pazopanib and lapatinib combination therapy in patients with advanced solid tumors Full Text Investigational New Drugs, October 8, 2012 Clinical Article

10 The high prevalence of chronic kidney disease-mineral bone disorders: A hospital-based cross-sectional study Full Text Indian Journal of Nephrology, October 8, 2012 Clinical Article

11 Costs of Illness Due to Cholera, Costs of Immunization and Cost-Effectiveness of an Oral Cholera Mass Vaccination Campaign in Zanzibar Full Text PLoS Neglected Tropical Diseases, October 8, 2012 Clinical Article

12 Investigating a cluster of vulvar cancer in young women: a cross-sectional study of genital human papillomavirus prevalence Full Text BMC Infectious Diseases, October 8, 2012

13 The I405V and Taq1B polymorphisms of the CETP gene differentially affect sub-clinical carotid atherosclerosis Full Text Lipids in Health and Disease, October 8, 2012

14 Expression of Shigella flexneri gluQ-rs gene is linked to dksA and controlled by a transcriptional terminator Full Text BMC Microbiology, October 8, 2012

15 Haemoglobinuria among children with severe malaria attending tertiary care in Ibadan, Nigeria Full Text Malaria Journal, October 8, 2012

16 Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials Full Text PLoS Neglected Tropical Diseases, October 8, 2012

17 Differential Infectivity by the Oral Route of Trypanosoma cruzi Lineages Derived from Y Strain Full Text PLoS Neglected Tropical Diseases, October 8, 2012

18 Predictors of mortality in connective tissue disease-associated pulmonary arterial hypertension: a cohort study Full Text Arthritis Research & Therapy, October 8, 2012

19 Functional relationship between high mobility group A1 (HMGA1) protein and insulin-like growth factor binding protein 3 (IGFBP-3) in human chondrocytes Full Text Arthritis Research & Therapy, October 8, 2012

20 Secretome analysis of chondroitin sulfate-treated chondrocytes reveals its anti-angiogenic, anti-inflammatory and anti-catabolic properties Full Text Arthritis Research & Therapy, October 8, 2012

483 available pages FirstPrevious 1 2 3 4 5 6 7 8 9 10 Next Last

Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine