1Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterolJACC - Journal of the American College of Cardiology  Full Text  Clinical Article
2Differential Effects of Adiposity on Pharmacodynamics of Basal Insulins NPH, Glargine, and Detemir in Type 2 DiabetesDiabetes Care  Full Text
3Phase I/II and Pharmacodynamic Study of Dovitinib (TKI258)-an Inhibitor of Fibroblast Growth Factor Receptors and VEGF Receptors-in Patients with Advanced MelanomaClinical Cancer Research  Full Text  Clinical Article
4Multicenter, Phase II Study of Axitinib, a Selective Second-Generation Inhibitor of Vascular Endothelial Growth Factor Receptors 1, 2, 3, in Patients with Metastatic MelanomaClinical Cancer Research  Full Text  Clinical Article
5A Phase 1 dose-escalation study of the safety and pharmacokinetics of once-daily oral foretinib, a multi-kinase inhibitor, in patients with solid tumorsInvestigational New Drugs  Full Text  Clinical Article
6A Phase I Dose Esclation Study of Tivantinib in Adult Pts w Metastatic Solid TumorsClinical Cancer Research  Full Text  Clinical Article
7Pam50 breast cancer subtyping by RT-QPCR and concordance with standard clinical molecular markersBMC Genomics  Full Text
8A prospective cohort study of health behavior profiles after age 50 and mortality riskBMC Public Health  Full Text
9Phase I and pharmacokinetic study of pazopanib and lapatinib combination therapy in patients with advanced solid tumorsInvestigational New Drugs  Full Text  Clinical Article
10The high prevalence of chronic kidney disease-mineral bone disorders: A hospital-based cross-sectional studyIndian Journal of Nephrology  Full Text  Clinical Article
1NIH-funded researchers identify genetic region associated with peanut allergyNational Institute of Allergy and Infectious Disease - News
2Shake it off? Not so easy for people with depression, new brain research suggestsUniversity of Michigan Health System
3Cystic fibrosis discovery may lead to new treatment strategy to help patients breathe easierUCSF News
4Prescription opioid analgesic use among adults: United States, 1999–2012U.S. National Center for Health Statistics News
5The numbers are in: 1.8m Australian smokers likely to die from their habitUniversity of Melbourne News
6A virtual reality check for medical studentsOhio State University News
7Million man study examines long-term effects of blocking inflammationUniversity of Cambridge News
8Sleeping over eight hours a day associated with greater risk of strokeUniversity of Cambridge News
9Widely used food additive promotes colitis, obesity and metabolic syndrome, research showsGeorgia State University News
10Could an HIV drug beat strep throat, flesh-eating bacteria?American Chemical Society News

Show Me:

Muscle strength in adolescence decreases CVD risk

As reported in BMC Medicine, adolescents (n=38588) with the highest tertile of muscle strength had a decreased risk of CVD (HR=0.88) compared to adolescents with the lowest tertile of muscle strength after 42 y of follow-up. Of note, low muscle strength in adolescence by itself had no effect on CVD risk in middle age (HR=0.99). In contrast, high muscle strength in adolescence significantly decreased the risk of CVD in middle age (HR=1.31).

Soluble TNF receptor II increased in MS patients

As reported in the Journal of Neuroimmunology, soluble tumor necrosis factor receptor II levels are increased in patients with untreated multiple sclerosis (n-161) compared to healthy controls (n=46), and the levels increased over a 2-year follow-up, but were not associated with the severity of disability.

Sleep duration linked to lung cancer risk

As reported in BMC Public Health, men (age range, 42-60 years) who slept < 7 h/night or > 8 h/night are at increased risk for lung cancer. Specifically, amongst current smokers, the HR for lung cancer in men who slept < 6.5 h/night or > 8 h/night was 2.23 and 2.09, respectively. It is thought that melatonin excretion and/or low-grade inflammation account for this observation.

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Clinical Pearls

Clinical Pearl from Smartest DocSerum C-peptide levels after breakfast are the most useful marker for identifying non-obese type 2 diabetics requiring multiple daily insulin injections.

Clinical Pearl from Smartest DocIn-hospital mortality and median survival time are similar among patients with hepatitis B virus-related liver cirrhosis experiencing their first episode of community-acquired spontaneous bacterial peritonitis (CA-SBP) or nosocomial spontaneous bacterial peritonitis (N-SBP)

Clinical Pearl from Smartest DocSpironolactone improves renal function and congestion in patients with acute decompensated chronic heart failure.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List