Internal Medicine News Articles

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Ranked, sorted, and summarized by MDLinx editors from the latest literature
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1 Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterol Full Text JACC - Journal of the American College of Cardiology, October 8, 2012 Original Publication Date: October 7, 2011    Clinical Article

2 Differential Effects of Adiposity on Pharmacodynamics of Basal Insulins NPH, Glargine, and Detemir in Type 2 Diabetes Full Text Diabetes Care, October 8, 2012 Original Publication Date: October 7, 2011

3 Phase I/II and Pharmacodynamic Study of Dovitinib (TKI258)-an Inhibitor of Fibroblast Growth Factor Receptors and VEGF Receptors-in Patients with Advanced Melanoma Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 7, 2011    Clinical Article

4 Multicenter, Phase II Study of Axitinib, a Selective Second-Generation Inhibitor of Vascular Endothelial Growth Factor Receptors 1, 2, 3, in Patients with Metastatic Melanoma Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 7, 2011    Clinical Article

5 A Phase 1 dose-escalation study of the safety and pharmacokinetics of once-daily oral foretinib, a multi-kinase inhibitor, in patients with solid tumors Full Text Investigational New Drugs, October 8, 2012    Clinical Article

6 A Phase I Dose Esclation Study of Tivantinib in Adult Pts w Metastatic Solid Tumors Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 7, 2011    Clinical Article

7 Pam50 breast cancer subtyping by RT-QPCR and concordance with standard clinical molecular markers Full Text BMC Genomics, October 8, 2012

8 A prospective cohort study of health behavior profiles after age 50 and mortality risk Full Text BMC Public Health, October 8, 2012

9 Phase I and pharmacokinetic study of pazopanib and lapatinib combination therapy in patients with advanced solid tumors Full Text Investigational New Drugs, October 8, 2012    Clinical Article

10 The high prevalence of chronic kidney disease-mineral bone disorders: A hospital-based cross-sectional study Full Text Indian Journal of Nephrology, October 8, 2012    Clinical Article

11 Costs of Illness Due to Cholera, Costs of Immunization and Cost-Effectiveness of an Oral Cholera Mass Vaccination Campaign in Zanzibar Full Text PLoS Neglected Tropical Diseases, October 8, 2012    Clinical Article

12 Investigating a cluster of vulvar cancer in young women: a cross-sectional study of genital human papillomavirus prevalence Full Text BMC Infectious Diseases, October 8, 2012

13 The I405V and Taq1B polymorphisms of the CETP gene differentially affect sub-clinical carotid atherosclerosis Full Text Lipids in Health and Disease, October 8, 2012

14 Expression of Shigella flexneri gluQ-rs gene is linked to dksA and controlled by a transcriptional terminator Full Text BMC Microbiology, October 8, 2012

15 Haemoglobinuria among children with severe malaria attending tertiary care in Ibadan, Nigeria Full Text Malaria Journal, October 8, 2012

16 Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials Full Text PLoS Neglected Tropical Diseases, October 8, 2012

17 Differential Infectivity by the Oral Route of Trypanosoma cruzi Lineages Derived from Y Strain Full Text PLoS Neglected Tropical Diseases, October 8, 2012

18 Predictors of mortality in connective tissue disease-associated pulmonary arterial hypertension: a cohort study Full Text Arthritis Research & Therapy, October 8, 2012

19 Functional relationship between high mobility group A1 (HMGA1) protein and insulin-like growth factor binding protein 3 (IGFBP-3) in human chondrocytes Full Text Arthritis Research & Therapy, October 8, 2012

20 Secretome analysis of chondroitin sulfate-treated chondrocytes reveals its anti-angiogenic, anti-inflammatory and anti-catabolic properties Full Text Arthritis Research & Therapy, October 8, 2012

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Clinical Pearls in Internal Medicine

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Highlights in Internal Medicine

Sleep duration linked to lung cancer risk

As reported in BMC Public Health, men (age range, 42-60 years) who slept < 7 h/night or > 8 h/night are at increased risk for lung cancer. Specifically, amongst current smokers, the HR for lung cancer in men who slept < 6.5 h/night or > 8 h/night was 2.23 and 2.09, respectively. It is thought that melatonin excretion and/or low-grade inflammation account for this observation.

Mean platelet volume predicts silent cerebral infarction

As reported in the Internal Medicine Journal, the mean platelet volume is increased in patients with a silent cerebral infarction than in those without (10.4 vs. 9.2 fL). The OR for silent cerebral infarction was 7.822 in patients in the highest mean platelet volume quartile compared to the lowest quartile.

Muscle strength in adolescence decreases CVD risk

As reported in BMC Medicine, adolescents (n=38588) with the highest tertile of muscle strength had a decreased risk of CVD (HR=0.88) compared to adolescents with the lowest tertile of muscle strength after 42 y of follow-up. Of note, low muscle strength in adolescence by itself had no effect on CVD risk in middle age (HR=0.99). In contrast, high muscle strength in adolescence significantly decreased the risk of CVD in middle age (HR=1.31).


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