Our team of medical editors read over 2,000 medical journals daily so you can stay current on today's latest Internal Medicine news in medical research, review articles and biomedical science. They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have Exclusive Author Commentary from the people who actually performed the clinical research.
1 Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterol Full Text JACC - Journal of the American College of Cardiology, October 8, 2012 Original Publication Date: October 7, 2011 Clinical Article
2 Differential Effects of Adiposity on Pharmacodynamics of Basal Insulins NPH, Glargine, and Detemir in Type 2 Diabetes Full Text Diabetes Care, October 8, 2012 Original Publication Date: October 7, 2011
3 Phase I/II and Pharmacodynamic Study of Dovitinib (TKI258)-an Inhibitor of Fibroblast Growth Factor Receptors and VEGF Receptors-in Patients with Advanced Melanoma Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 7, 2011 Clinical Article
4 Multicenter, Phase II Study of Axitinib, a Selective Second-Generation Inhibitor of Vascular Endothelial Growth Factor Receptors 1, 2, 3, in Patients with Metastatic Melanoma Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 7, 2011 Clinical Article
5 A Phase 1 dose-escalation study of the safety and pharmacokinetics of once-daily oral foretinib, a multi-kinase inhibitor, in patients with solid tumors Full Text Investigational New Drugs, October 8, 2012 Clinical Article
6 A Phase I Dose Esclation Study of Tivantinib in Adult Pts w Metastatic Solid Tumors Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 7, 2011 Clinical Article
7 Pam50 breast cancer subtyping by RT-QPCR and concordance with standard clinical molecular markers Full Text BMC Genomics, October 8, 2012
8 A prospective cohort study of health behavior profiles after age 50 and mortality risk Full Text BMC Public Health, October 8, 2012
9 Phase I and pharmacokinetic study of pazopanib and lapatinib combination therapy in patients with advanced solid tumors Full Text Investigational New Drugs, October 8, 2012 Clinical Article
10 The high prevalence of chronic kidney disease-mineral bone disorders: A hospital-based cross-sectional study Full Text Indian Journal of Nephrology, October 8, 2012 Clinical Article
11 Costs of Illness Due to Cholera, Costs of Immunization and Cost-Effectiveness of an Oral Cholera Mass Vaccination Campaign in Zanzibar Full Text PLoS Neglected Tropical Diseases, October 8, 2012 Clinical Article
12 Investigating a cluster of vulvar cancer in young women: a cross-sectional study of genital human papillomavirus prevalence Full Text BMC Infectious Diseases, October 8, 2012
13 The I405V and Taq1B polymorphisms of the CETP gene differentially affect sub-clinical carotid atherosclerosis Full Text Lipids in Health and Disease, October 8, 2012
14 Expression of Shigella flexneri gluQ-rs gene is linked to dksA and controlled by a transcriptional terminator Full Text BMC Microbiology, October 8, 2012
15 Haemoglobinuria among children with severe malaria attending tertiary care in Ibadan, Nigeria Full Text Malaria Journal, October 8, 2012
16 Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials Full Text PLoS Neglected Tropical Diseases, October 8, 2012
17 Differential Infectivity by the Oral Route of Trypanosoma cruzi Lineages Derived from Y Strain Full Text PLoS Neglected Tropical Diseases, October 8, 2012
18 Predictors of mortality in connective tissue disease-associated pulmonary arterial hypertension: a cohort study Full Text Arthritis Research & Therapy, October 8, 2012
19 Functional relationship between high mobility group A1 (HMGA1) protein and insulin-like growth factor binding protein 3 (IGFBP-3) in human chondrocytes Full Text Arthritis Research & Therapy, October 8, 2012
20 Secretome analysis of chondroitin sulfate-treated chondrocytes reveals its anti-angiogenic, anti-inflammatory and anti-catabolic properties Full Text Arthritis Research & Therapy, October 8, 2012
As reported in BMC Medicine, adolescents (n=38588) with the highest tertile of muscle strength had a decreased risk of CVD (HR=0.88) compared to adolescents with the lowest tertile of muscle strength after 42 y of follow-up. Of note, low muscle strength in adolescence by itself had no effect on CVD risk in middle age (HR=0.99). In contrast, high muscle strength in adolescence significantly decreased the risk of CVD in middle age (HR=1.31).
As reported in BMC Public Health, men (age range, 42-60 years) who slept < 7 h/night or > 8 h/night are at increased risk for lung cancer. Specifically, amongst current smokers, the HR for lung cancer in men who slept < 6.5 h/night or > 8 h/night was 2.23 and 2.09, respectively. It is thought that melatonin excretion and/or low-grade inflammation account for this observation.
As reported in the Journal of Neuroimmunology, soluble tumor necrosis factor receptor II levels are increased in patients with untreated multiple sclerosis (n-161) compared to healthy controls (n=46), and the levels increased over a 2-year follow-up, but were not associated with the severity of disability.
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