Full Text Articles in Internal Medicine & General Medicine

1Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterolJACC - Journal of the American College of Cardiology, October 08, 2012  Full Text  Clinical Article
2Differential Effects of Adiposity on Pharmacodynamics of Basal Insulins NPH, Glargine, and Detemir in Type 2 DiabetesDiabetes Care, October 08, 2012  Full Text
3Phase I/II and Pharmacodynamic Study of Dovitinib (TKI258)-an Inhibitor of Fibroblast Growth Factor Receptors and VEGF Receptors-in Patients with Advanced MelanomaClinical Cancer Research, October 08, 2012  Full Text  Clinical Article
4Multicenter, Phase II Study of Axitinib, a Selective Second-Generation Inhibitor of Vascular Endothelial Growth Factor Receptors 1, 2, 3, in Patients with Metastatic MelanomaClinical Cancer Research, October 08, 2012  Full Text  Clinical Article
5A Phase 1 dose-escalation study of the safety and pharmacokinetics of once-daily oral foretinib, a multi-kinase inhibitor, in patients with solid tumorsInvestigational New Drugs, October 08, 2012  Full Text  Clinical Article
6A Phase I Dose Esclation Study of Tivantinib in Adult Pts w Metastatic Solid TumorsClinical Cancer Research, October 08, 2012  Full Text  Clinical Article
7Pam50 breast cancer subtyping by RT-QPCR and concordance with standard clinical molecular markersBMC Genomics, October 08, 2012  Full Text
8A prospective cohort study of health behavior profiles after age 50 and mortality riskBMC Public Health, October 08, 2012  Full Text
9Phase I and pharmacokinetic study of pazopanib and lapatinib combination therapy in patients with advanced solid tumorsInvestigational New Drugs, October 08, 2012  Full Text  Clinical Article
10The high prevalence of chronic kidney disease-mineral bone disorders: A hospital-based cross-sectional studyIndian Journal of Nephrology, October 08, 2012  Full Text  Clinical Article
1Study may explain low blood oxygen levels for cystic fibrosis patients with infected lungsSt. Michael's Hospital, March 30, 2015
2Yale team defines genetic subtypes of asthmaYale School of Medicine News, March 30, 2015
3Researchers reverse type 2 diabetes and fatty liver diseaseUniversity of Copenhagen Faculty of Health and Medical Sciences News, March 30, 2015
4Structure of genetic messenger molecules reveals key role in diseasesUniversity College London New, March 30, 2015
5How our DNA may prevent bowel cancerUniversity of Melbourne News, March 30, 2015
6Combination therapy boosts antiviral response to chronic infectionYale School of Medicine News, March 30, 2015
7Yale med student finds link between weight gain after HIV treatment and mortalityYale School of Medicine News, March 30, 2015
8Danish Researchers' breakthrough identification of important proteinUniversity of Copenhagen Faculty of Health and Medical Sciences News, March 30, 2015
9Stem cells make similar decisions to humansUniversity of Copenhagen Faculty of Health and Medical Sciences News, March 30, 2015
10UTMB scientists use immunotherapy to reduce memory problems with Alzheimer's DiseaseUniversity of Texas Medical Branch at Galveston, March 30, 2015

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Sleep duration linked to lung cancer risk

As reported in BMC Public Health, men (age range, 42-60 years) who slept < 7 h/night or > 8 h/night are at increased risk for lung cancer. Specifically, amongst current smokers, the HR for lung cancer in men who slept < 6.5 h/night or > 8 h/night was 2.23 and 2.09, respectively. It is thought that melatonin excretion and/or low-grade inflammation account for this observation.

Muscle strength in adolescence decreases CVD risk

As reported in BMC Medicine, adolescents (n=38588) with the highest tertile of muscle strength had a decreased risk of CVD (HR=0.88) compared to adolescents with the lowest tertile of muscle strength after 42 y of follow-up. Of note, low muscle strength in adolescence by itself had no effect on CVD risk in middle age (HR=0.99). In contrast, high muscle strength in adolescence significantly decreased the risk of CVD in middle age (HR=1.31).

Mean platelet volume predicts silent cerebral infarction

As reported in the Internal Medicine Journal, the mean platelet volume is increased in patients with a silent cerebral infarction than in those without (10.4 vs. 9.2 fL). The OR for silent cerebral infarction was 7.822 in patients in the highest mean platelet volume quartile compared to the lowest quartile.

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