Internal Medicine News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (291) Full Text Articles (9654) Focus on Diabetes Mellitus

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Rheumatoid Arthritis

1 Safety profile of protein kinase inhibitors in rheumatoid arthritis: systematic review and meta-analysis Annals of Rheumatic Diseases, June 1, 2013 Evidence Based Medicine Review Article Clinical Article

2 Kinase inhibitors: A new tool for the treatment of Rheumatoid Arthritis Clinical Immunology, June 1, 2013 Clinical Article

3 Validation of methotrexate-first strategy in early poor prognosis rheumatoid arthritis: Results from a randomized, double-blind, 2-year trial Arthritis & Rheumatism, June 1, 2013 Clinical Article

4 Induced abortions in women with rheumatoid arthritis on methotrexate Arthritis Care & Research , June 1, 2013 Clinical Article

5 Very early rheumatoid arthritis as a predictor of remission: a multicentre real life prospective study Annals of Rheumatic Diseases, June 1, 2013 Clinical Article

6 Serum Interleukin 6 Before and After Therapy with Tocilizumab Is a Principal Biomarker in Patients with Rheumatoid Arthritis The Journal of Rheumatology, June 1, 2013 Clinical Article

7 Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies Annals of Rheumatic Diseases, June 1, 2013 Clinical Article

8 Use of Lipid-lowering Agents in Rheumatoid Arthritis: A Population-based Cohort Study The Journal of Rheumatology, May 14, 2013 Clinical Article
Exclusive Author Commentary

9 The risk of gastrointestinal perforations in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the BSRBR-RA Annals of Rheumatic Diseases, May 14, 2013 Clinical Article

10 Safety of Abatacept Administered Intravenously in Treatment of Rheumatoid Arthritis: Integrated Analyses of up to 8 Years of Treatment from the Abatacept Clinical Trial Program The Journal of Rheumatology, May 14, 2013 Clinical Article

11 The impact of statin use on lipid levels in statin-naive patients with rheumatoid arthritis (RA) vs. non-RA subjects: Results from a population-based study Arthritis Care & Research , May 14, 2013 Clinical Article

12 Association between testosterone levels and risk of future rheumatoid arthritis in men: a population-based case-control study Annals of Rheumatic Diseases, May 14, 2013 Clinical Article

13 Efficacy and Safety of Belimumab in Patients with Rheumatoid Arthritis: A Phase II, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study The Journal of Rheumatology, May 14, 2013 Clinical Article

14 Oral administration of GLPG0259, an inhibitor of MAPKAPK5, a new target for the treatment of rheumatoid arthritis: a phase II, randomised, double-blind, placebo-controlled, multicentre trial Annals of Rheumatic Diseases, May 14, 2013 Clinical Article

15 Remission in patients with active rheumatoid arthritis by tocilizumab treatment in routine clinical practice: results from 3 years of prospectively registered data Modern Rheumatology, May 14, 2013 Clinical Article

16 Longterm Effects of Rituximab on B Cell Counts and Autoantibody Production in Rheumatoid Arthritis: Use of High-sensitivity Flow Cytometry for More Sensitive Assessment of B Cell Depletion The Journal of Rheumatology, May 14, 2013 Clinical Article

17 Clinical Response Within 12 Weeks as a Predictor of Future Low Disease Activity in Patients with Early RA: Results from the TEAR Trial The Journal of Rheumatology, May 14, 2013 Clinical Article

18 Adalimumab: 8 years of experience in rheumatoid arthritis International Journal of Clinical Rheumatology, May 14, 2013 Clinical Article

19 EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis Annals of Rheumatic Diseases, April 14, 2013 Clinical Article

20 Carotid ultrasound is useful for the cardiovascular risk stratification of patients with rheumatoid arthritis: results of a population-based study Annals of Rheumatic Diseases, April 14, 2013 Clinical Article

21 Safety of Rituximab in Combination with Other Biologic Disease-modifying Antirheumatic Drugs in Rheumatoid Arthritis: An Open-label Study The Journal of Rheumatology, April 14, 2013 Clinical Article

22 Long-term therapeutic effects and safety of tacrolimus added to methotrexate in patients with rheumatoid arthritis Rheumatology International, April 14, 2013 Clinical Article

Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Med Articles

Last month's top read Top Articles of 2012

1 Aspirin: Its risks, benefits, and optimal use in preventing cardiovascular events Cleveland Clinic Journal of Medicine, May 8, 2013 Free full text

2 Relationship between 25-Hydroxyvitamin D and All-cause and Cardiovascular Disease Mortality American Journal of Medicine, May 24, 2013 Review Article

3 The effect of topiramate on weight loss in patients with type 2 diabetes Journal of Research in Medical Sciences, May 14, 2013 Evidence Based Medicine

4 The Prevalence and Prognostic Role of Vitamin D Deficiency in Patients with Acute Coronary Syndrome Heart, Lung, and Circulation, April 30, 2013

5 Egg consumption and risk of cardiovascular diseases and diabetes: A meta-analysis Atherosclerosis, May 8, 2013 Evidence Based Medicine Review Article

6 Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials British Medical Journal, April 25, 2013 Evidence Based Medicine Review Article

7 An Update on the Cardiovascular Pleiotropic Effects of Milk and Milk Products The Journal of Clinical Hypertension, May 7, 2013 Review Article

8 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013

9 Anger and the Heart: Perspectives on Cardiac Risk, Mechanisms and Interventions Progress in Cardiovascular Diseases , May 1, 2013

10 1:1 atrial-flutter. Prevalence and clinical characteristics International Journal of Cardiology, May 2, 2013

11 Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Non-Linear Association Journal of Clinical Endocrinology and Metabolism, March 27, 2013
Exclusive Author Commentary

12 New Oral Anticoagulants in Non-Valvular Atrial Fibrillation High Blood Pressure & Cardiovascular Prevention, May 13, 2013

13 Acute myocardial infarction leads to acceleration of atherosclerosis Atherosclerosis, May 1, 2013 Review Article

14 An Anxious Heart: Anxiety and the Onset of Cardiovascular Diseases Progress in Cardiovascular Diseases , May 1, 2013

15 Primary Prevention of Cardiovascular Disease with a Mediterranean Diet New England Journal of Medicine, April 8, 2013 Free full text

16 Cost-effectiveness of a coronary heart disease secondary prevention program in patients with myocardial infarction: results from a randomised controlled trial BMC Cardiovascular Disorders, May 7, 2013 Free full text

17 Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial The Lancet, May 16, 2013

18 Risk of venous thromboembolism associated with peripherally inserted central catheters: a systematic review and meta-analysis The Lancet, May 20, 2013

19 The Effects of Ezetimibe/Simvastatin versus Simvastatin Monotherapy on Platelet and Inflammatory Biomarkers in Patients with Metabolic Syndrome Cardiology, May 9, 2013

20 Association Between a Hospital's Rate of Cardiac Arrest Incidence and Cardiac Arrest Survival JAMA Internal Medicine, May 21, 2013 Evidence Based Medicine

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Med Articles

Other Topics in Internal Medicine