Internal Medicine News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (248) Full Text Articles (9654) Focus on Diabetes Mellitus

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Diabetes Mellitus

1 Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure Circulation: Heart Failure, June 19, 2013 Evidence Based Medicine Review Article Clinical Article

2 Metabolically healthy but obese, a matter of time? Findings from the prospective Pizarra study Journal of Clinical Endocrinology and Metabolism, June 19, 2013 Clinical Article

3 Postprandial serum C-peptide value is the optimal index to identify patients with non-obese type 2 diabetes who require multiple daily insulin injection: analysis of C-peptide values before and after short-term intensive insulin therapy Journal of Diabetes Investigation, June 19, 2013 Review Article Clinical Article

4 Very Low Calorie Diet Mimics the Early Beneficial Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity and Beta-Cell Function in Type 2 Diabetic Patients Diabetes, June 19, 2013 Review Article

5 Mortality outcomes of different sulfonylurea drugs. The results of a 14-year cohort study of type 2 diabetic patients European Journal of Endocrinology, June 19, 2013 Clinical Article

6 Randomized Trial of Continuous Subcutaneous Delivery of Exenatide by ITCA 650 Versus Twice-Daily Exenatide Injections in Metformin-Treated Type 2 Diabetes Diabetes Care, June 19, 2013 Clinical Article

7 Vascular function and atherosclerosis progression after 1 y of flavonoid intake in statin-treated postmenopausal women with type 2 diabetes: a double-blind randomized controlled trial American Journal of Clinical Nutrition, June 19, 2013 Clinical Article

8 Insulin resistance and risk of incident heart failure Circulation: Heart Failure, June 19, 2013 Clinical Article

9 Effects of niacin on the incidence of new onset diabetes and cardiovascular events in patients with normoglycaemia and impaired fasting glucose International Journal of Clinical Practice, June 19, 2013 Clinical Article

10 Low-Carbohydrate Diet for the Treatment of Gestational Diabetes: A randomized controlled trial Diabetes Care, June 19, 2013 Clinical Article

11 Adding Once-Daily Lixisenatide for Type 2 Diabetes Inadequately Controlled by Established Basal Insulin: A 24-week, randomized, placebo-controlled comparison (GetGoal-L) Diabetes Care, June 19, 2013 Clinical Article

12 Circulating Vitamin D Metabolites and Subclinical Atherosclerosis in Type 1 Diabetes Diabetes Care, June 19, 2013 Clinical Article

13 Discordant effects of rosiglitazone on novel inflammatory biomarkers American Heart Journal, June 19, 2013 Clinical Article

14 Characteristics Associated With Maintenance of Mean A1C <6.5% in People With Dysglycemia in the ORIGIN Trial Diabetes Care, June 19, 2013 Clinical Article

15 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, May 2, 2013 Clinical Article

16 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, May 2, 2013 Clinical Article

17 Preeclampsia as a Risk Factor for Diabetes: A Population-Based Cohort Study Full Text PLoS Medicine, May 2, 2013 Clinical Article

18 Coronary artery calcium score prediction of all cause mortality and cardiovascular events in people with type 2 diabetes: systematic review and meta-analysis Full Text British Medical Journal, May 2, 2013 Evidence Based Medicine Review Article

19 Chronic Kidney Disease and Diabetes Mellitus Predict Resistance to Vitamin D Replacement Therapy The American Journal of the Medical Sciences, May 2, 2013 Clinical Article

20 Changes in trabecular bone microarchitecture in postmenopausal women with and without type 2 diabetes: a two year longitudinal study Full Text BMC Musculoskeletal Disorders, May 2, 2013 Clinical Article

21 Efficacy and Safety of Lixisenatide Once-Daily Morning or Evening Injections in Type 2 Diabetes Inadequately Controlled on Metformin (GetGoal-M) Diabetes Care, May 2, 2013 Clinical Article

22 Meta-Analysis of Impact of Different Types and Doses of Statins on New-Onset Diabetes Mellitus The American Journal of Cardiology, April 10, 2013 Evidence Based Medicine Review Article

23 Elevated 1-Hour Postload Plasma Glucose Levels Identify Subjects With Normal Glucose Tolerance but Impaired {beta}-Cell Function, Insulin Resistance, and Worse Cardiovascular Risk Profile: The GENFIEV Study Journal of Clinical Endocrinology and Metabolism, April 10, 2013 Clinical Article

Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

Read the article summary

CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Med Articles

Last month's top read Top Articles of 2012

1 Aspirin: Its risks, benefits, and optimal use in preventing cardiovascular events Cleveland Clinic Journal of Medicine, May 8, 2013 Free full text

2 Relationship between 25-Hydroxyvitamin D and All-cause and Cardiovascular Disease Mortality American Journal of Medicine, May 24, 2013 Review Article

3 The effect of topiramate on weight loss in patients with type 2 diabetes Journal of Research in Medical Sciences, May 14, 2013 Evidence Based Medicine

4 The Prevalence and Prognostic Role of Vitamin D Deficiency in Patients with Acute Coronary Syndrome Heart, Lung, and Circulation, April 30, 2013

5 Egg consumption and risk of cardiovascular diseases and diabetes: A meta-analysis Atherosclerosis, May 8, 2013 Evidence Based Medicine Review Article

6 Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials British Medical Journal, April 25, 2013 Evidence Based Medicine Review Article

7 An Update on the Cardiovascular Pleiotropic Effects of Milk and Milk Products The Journal of Clinical Hypertension, May 7, 2013 Review Article

8 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013

9 Anger and the Heart: Perspectives on Cardiac Risk, Mechanisms and Interventions Progress in Cardiovascular Diseases , May 1, 2013

10 1:1 atrial-flutter. Prevalence and clinical characteristics International Journal of Cardiology, May 2, 2013

11 Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Non-Linear Association Journal of Clinical Endocrinology and Metabolism, March 27, 2013
Exclusive Author Commentary

12 New Oral Anticoagulants in Non-Valvular Atrial Fibrillation High Blood Pressure & Cardiovascular Prevention, May 13, 2013

13 Acute myocardial infarction leads to acceleration of atherosclerosis Atherosclerosis, May 1, 2013 Review Article

14 An Anxious Heart: Anxiety and the Onset of Cardiovascular Diseases Progress in Cardiovascular Diseases , May 1, 2013

15 Primary Prevention of Cardiovascular Disease with a Mediterranean Diet New England Journal of Medicine, April 8, 2013 Free full text

16 Cost-effectiveness of a coronary heart disease secondary prevention program in patients with myocardial infarction: results from a randomised controlled trial BMC Cardiovascular Disorders, May 7, 2013 Free full text

17 Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial The Lancet, May 16, 2013

18 Risk of venous thromboembolism associated with peripherally inserted central catheters: a systematic review and meta-analysis The Lancet, May 20, 2013

19 The Effects of Ezetimibe/Simvastatin versus Simvastatin Monotherapy on Platelet and Inflammatory Biomarkers in Patients with Metabolic Syndrome Cardiology, May 9, 2013

20 Association Between a Hospital's Rate of Cardiac Arrest Incidence and Cardiac Arrest Survival JAMA Internal Medicine, May 21, 2013 Evidence Based Medicine

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Med Articles

Other Topics in Internal Medicine