Internal Medicine News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

Substance Abuse

1 Is methoxydine a new rapid acting antidepressant for the treatment of depression in alcoholics? Medical Hypotheses, May 18, 2013 Clinical Article

2 Prospective study of substance-induced and independent major depressive disorder among individuals with substance use disorders in a nationally representative sample Depression and Anxiety, May 18, 2013 Clinical Article

3 Alcohol Use Disorders and Mortality: A Systematic Review and Meta-Analysis Addiction, May 18, 2013 Evidence Based Medicine Review Article

4 The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer Carcinogenesis, May 18, 2013 Clinical Article

5 Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: A randomized clinical trial Clinical Nutrition, May 18, 2013 Clinical Article

6 Moderate alcohol use and health: A consensus paper Nutrition, Metabolism & Cardiovascular Diseases, May 18, 2013 Review Article

7 Conduct Disorder and Initiation of Substance Use: A Prospective Longitudinal Study Journal of the American Academy of Child & Adolescent Psychiatry, May 18, 2013 Clinical Article

8 Alcoholic Beverage Consumption by Adults Compared to Dietary Guidelines: Results of the National Health and Nutrition Examination Survey, 2009-2010 Journal of the Academy of Nutrition and Dietetics, May 18, 2013 Clinical Guideline Clinical Article

9 Alcohol consumption before and after breast cancer diagnosis: associations with survival from breast cancer, cardiovascular disease, and other causes Journal of Clinical Oncology, May 18, 2013

10 The triggering effect of alcohol and illicit drugs on violent crime in a remand prison population: A case crossover study Drug and Alcohol Dependence, May 18, 2013 Clinical Article

11 Examining Alcohols Contribution to the US African-American/White Cirrhosis Mortality Differential from 1950 to 2002 Alcohol and Alcoholism , May 18, 2013 Clinical Article

12 Public opinion on imposing restrictions to people with an alcohol- or drug addiction: a cross-sectional survey Social Psychiatry and Psychiatric Epidemiology, May 18, 2013 Clinical Article

13 Micromorphological changes in cardiac tissue of drug-related deaths with emphasis on chronic illicit opioid abuse Addiction, May 18, 2013 Clinical Article

14 Alcohol consumption and risk of lymphoid and myeloid neoplasms: Results of the Netherlands cohort study International Journal of Cancer, April 28, 2013

15 A randomised, double-blind, placebo-controlled, efficacy study of nalmefene, as-needed use, in patients with alcohol dependence European Neuropsychopharmacology, April 28, 2013 Clinical Article

16 Aerobic Exercise Moderates the Effect of Heavy Alcohol Consumption on White Matter Damage Alcoholism: Clinical and Experimental Research, April 28, 2013 Clinical Article

17 Long-term alcohol and caffeine intake and risk of sudden cardiac death in women American Journal of Clinical Nutrition, April 28, 2013 Clinical Article

18 Randomized controlled trial of cognitive behaviour therapy for comorbid post-traumatic stress disorder and alcohol use disorders Addiction, April 28, 2013 Clinical Article

19 Alcohol Intake and Triglycerides/High-Density Lipoprotein Cholesterol Ratio in Men with Hypertension American Journal of Hypertension, April 28, 2013 Clinical Article

20 Substance Use Following Bariatric Weight Loss Surgery JAMA Surgery, April 28, 2013 Review Article

21 Dose- and Gender-dependent Interactions between Coffee Consumption and Serum GGT Activity in Alcohol Consumers Alcohol and Alcoholism , April 28, 2013 Clinical Article

22 Management of Hepatitis C Virus Infection in Heavy Drinkers Alcohol and Alcoholism , April 28, 2013 Clinical Article

23 The Impact of Alcohol and Energy Drink Consumption on Intoxication and Risk-Taking Behavior Alcoholism: Clinical and Experimental Research, April 28, 2013 Clinical Article

24 Estimating the mediating effect of different biomarkers on the relation of alcohol consumption with the risk of type 2 diabetes Annals of Epidemiology , April 28, 2013 Clinical Article

25 Exploring causal associations between alcohol and coronary heart disease risk factors: findings from a Mendelian randomization study in the Copenhagen General Population Study European Heart Journal, March 24, 2013 Clinical Article

26 Predictors of initial and sustained remission from alcohol use disorders: findings from the 30-year follow-up of the san diego prospective study Alcoholism: Clinical and Experimental Research, March 24, 2013 Clinical Article

27 The Effects of Chronic Cigarette Smoking on Cognitive Recovery During Early Abstinence from Alcohol Alcoholism: Clinical and Experimental Research, March 24, 2013 Clinical Article

Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013

2 Primary Prevention of Cardiovascular Disease with a Mediterranean Diet New England Journal of Medicine, April 8, 2013 Free full text

3 Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Non-Linear Association Journal of Clinical Endocrinology and Metabolism, March 27, 2013
Exclusive Author Commentary

4 Advances in Stroke Prevention in Atrial Fibrillation: Enhanced Risk Stratification Combined With the Newer Oral Anticoagulants Clinical Cardiology, April 11, 2013 Free full text Review Article

5 Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials British Medical Journal, April 25, 2013 Evidence Based Medicine Review Article

6 The Risk of Taking Ascorbic Acid JAMA Internal Medicine, February 5, 2013

7 Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial The Lancet, April 18, 2013

8 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013

9 Enalapril And Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients with Malignant Hemopathies. The OVERCOME Trial JACC - Journal of the American College of Cardiology, April 12, 2013

10 Drug Interactions with Grapefruit Juice British Journal of Medical Practitioners, February 12, 2013 Free full text

11 Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial European Heart Journal, April 22, 2013

12 Pulmonary hypertension: diagnosis and management British Medical Journal, April 23, 2013 Review Article

13 Infective Endocarditis New England Journal of Medicine, April 12, 2013

14 Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels -- Results from a randomized trial European Journal of Internal Medicine , April 11, 2013

15 Vitamin D and Calcium Supplementation to Prevent Fractures in Adults: U.S. Preventive Services Task Force Recommendation Statement Annals of Internal Medicine, February 26, 2013 Clinical Guideline

16 Infective Endocarditis New England Journal of Medicine, April 24, 2013 Review Article

17 Osteoporosis treatment European Journal of Internal Medicine , April 24, 2013

18 Bone mineral density testing: Is a T score enough to determine the screening interval? Cleveland Clinic Journal of Medicine, April 3, 2013 Free full text

19 The impact of coffee on health Maturitas, February 26, 2013

20 Efficacy and safety of linagliptin in type 2 diabetes subjects at high risk for renal and cardiovascular disease: a pooled analysis of six phase III clinical trials Cardiovascular Diabetology, April 12, 2013 Free full text

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine