What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.
Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.
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121 Prediction of rectum and bladder morbidity following radiotherapy of prostate cancer based on motion-inclusive dose distributions Radiotherapy & Oncology, May 17, 2013 Review Article
122 Antidepressants in the treatment of depression/depressive symptoms in cancer patients: a systematic review and meta-analysis Full Text BMC Psychiatry, May 17, 2013 Evidence Based Medicine Review Article
123 Phase I study of highly selective inhibitor of VEGFR tyrosine kinase, tivozanib, in Japanese patients with solid tumors Cancer Science, May 17, 2013 Review Article
124 Expression profiling of metastatic renal cell carcinoma using gene set enrichment analysis International Journal of Urology, May 17, 2013 Clinical Article
125 Senescent Fibroblasts Enhance Early Skin Carcinogenic Events via a Paracrine MMP-PAR-1 Axis PLOS ONE, May 17, 2013 Review Article
126 The Redox State of Cytochrome C Modulates Resistance to Methotrexate in Human MCF7 Breast Cancer Cells PLOS ONE, May 17, 2013 Review Article
127 Late toxicity and biochemical control in 554 prostate cancer patients treated with and without dose escalated image guided radiotherapy Radiotherapy & Oncology, May 17, 2013 Review Article
128 Intravesical bacille calmette-guerin eradicates bacteriuria in antibiotic-naive bladder cancer patients Full Text European Urology, May 16, 2013 Clinical Article
129 Reflex immunocyt testing for the diagnosis of bladder cancer in patients with atypical urine cytology Full Text European Urology, May 16, 2013 Clinical Article
130 A Risk for Hepatocellular Carcinoma Persists Long-term After Sustained Virologic Response in Patients With Hepatitis C-Associated Liver Cirrhosis Clinical Infectious Diseases, May 16, 2013 Clinical Article
131 Second and subsequent tumours among 1927 retinoblastoma patients diagnosed in Britain 1951-2004 British Journal of Cancer, May 16, 2013 Clinical Article
132 The effects of soy consumption before diagnosis on breast cancer survival: the multiethnic cohort study Nutrition and Cancer, May 16, 2013 Clinical Article
133 Clinical implementation of quality of life instruments and prediction tools for localized prostate cancer: results from a national survey of radiation oncologists and urologists The Journal of Urology, May 16, 2013 Clinical Article
134 Decrease of 5-Hydroxymethylcytosine Is Associated with Progression of Hepatocellular Carcinoma through Downregulation of TET1 PLOS ONE, May 16, 2013 Evidence Based Medicine
135 CCN3 promotes prostate cancer bone metastasis by modulating the tumor–bone microenvironment through RANKL-dependent pathway Carcinogenesis, May 16, 2013 Clinical Article
136 Update on non-melanoma skin cancer and the value of dermoscopy in its diagnosis and treatment monitoring Expert Review of Anticancer Therapy, May 16, 2013 Clinical Article
137 Hospital-based transfusion error tracking from 2005 to 2010: identifying the key errors threatening patient transfusion safety Transfusion, May 16, 2013 Clinical Article
138 Human epidermal growth factor receptor-2 expression in primary and metastatic gastric cancer International Journal of Clinical Oncology, May 16, 2013 Review Article
139 Patient and family experiences of palliative care in hospital: ?What do we know? An integrative review Palliative Medicine, May 16, 2013 Review Article
140 Analysis of serum proteome profiles in nasopharyngeal carcinoma with different radiosensitivity Clinical and Translational Oncology, May 16, 2013 Review Article
Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).
Read the article summaryResearchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.
Read the article summaryResearchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.
Read the article summary1 New Perspectives of Curcumin in Cancer Prevention Cancer Prevention Research, April 17, 2013 Review Article
2 Leukaemia update. Part 1: diagnosis and management British Medical Journal, April 9, 2013 Review Article
3 Treatment of Iron-deficiency Anemia in Patients with Subclinical Hypothyroidism American Journal of Medicine, April 18, 2013
4 Statin use and risk of prostate cancer and high-grade prostate cancer: results from the REDUCE study Prostate Cancer & Prostatic Diseases, April 11, 2013
5 Enalapril And Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients with Malignant Hemopathies. The OVERCOME Trial JACC - Journal of the American College of Cardiology, April 12, 2013
6 Iron deficiency in chronic heart failure: An international pooled analysis American Heart Journal, April 1, 2013
7 The changing paradigm of CLL management European Journal of Internal Medicine , April 17, 2013 Review Article
8 Efficacy and safety of dabigatran etexilate and warfarin in real world patients with atrial fibrillation: A prospective nationwide cohort study JACC - Journal of the American College of Cardiology, April 15, 2013
9 Strategy for detection of prostate cancer based on relation between prostate specific antigen at age 40-55 and long term risk of metastasis: case-control study British Medical Journal, April 23, 2013
10 The role of Helicobacter pylori infection in hematological disorders European Journal of Internal Medicine , March 29, 2013 Review Article
11 Red flags to screen for malignancy in patients with low-back pain Cochrane Reviews, March 8, 2013
12 Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013 Mayo Clinic Proceedings, April 9, 2013 Free full text Clinical Guideline
13 Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality European Urology, March 27, 2013 Free full text
14 Cervical cancer screening: What’s new and what’s coming? Cleveland Clinic Journal of Medicine, March 19, 2013
15 Effective elimination of dabigatran by haemodialysis Thrombosis and Haemostasis, April 12, 2013
16 Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly The Lancet Oncology, May 10, 2012
17 The impact of coffee on health Maturitas, February 26, 2013
18 MicroRNA Profiling Can Classify Acute Leukemias of Ambiguous Lineage as Either Acute Myeloid Leukemia or Acute Lymphoid Leukemia Clinical Cancer Research, April 9, 2013
19 Ideal Cardiovascular Health Is Inversely Associated With Incident Cancer Circulation, March 27, 2013
20 Thromboprophylaxis for trauma patients Cochrane Reviews, April 1, 2013 Review Article
Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more
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