Internal Medicine - Hematology/Oncology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (18) Full Text Articles (1465) Focus on Substance Abuse

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

81 Regorafenib inhibits growth, angiogenesis and metastasis in a highly aggressive, orthotopic colon cancer model Molecular Cancer Therapeutics, May 14, 2013 Clinical Article

82 The role of the red cell membrane in thrombin generation Thrombosis Research, May 14, 2013 Review Article

83 The New Oral Anticoagulants in Clinical Practice Mayo Clinic Proceedings, May 13, 2013 Clinical Article

84 A No-Prophylaxis Platelet-Transfusion Strategy for Hematologic Cancers New England Journal of Medicine, May 13, 2013 Evidence Based Medicine

85 Rutosides for prevention of post-thrombotic syndrome Cochrane Reviews, May 13, 2013 Clinical Article

86 Novel Immunotherapeutic Strategies in Development for Renal Cell Carcinoma Full Text European Urology, May 13, 2013 Review Article

87 Percutaneous Laser Ablation of Metastatic Lymph Nodes in the Neck From Papillary Thyroid Carcinoma: Preliminary Results Journal of Clinical Endocrinology and Metabolism, May 13, 2013 Clinical Article

88 Targeting the CD20 and CXCR4 Pathways in Non Hodgkin Lymphoma with Rituximab and high affinity CXCR4 antagonist BKT140 Clinical Cancer Research, May 13, 2013 Clinical Article

89 Evaluation of Food Effect on Pharmacokinetics of Vismodegib in Advanced Solid Tumor Patients Clinical Cancer Research, May 13, 2013 Clinical Article

90 In Vitro and In Vivo Antitumor Activity of a Novel Alkylating Agent, Melphalan-Flufenamide, against Multiple Myeloma Cells Clinical Cancer Research, May 13, 2013 Clinical Article

91 Phase I Study of U3-1287, a Fully Human Anti-HER3 Monoclonal Antibody, in Patients with Advanced Solid Tumors Clinical Cancer Research, May 13, 2013 Clinical Article

92 Chemoprevention of Lung Squamous Cell Carcinoma by Ginseng Cancer Prevention Research, May 13, 2013 Clinical Article

93 The metastatic microenvironment: Lung-derived factors control the viability of neuroblastoma lung metastasis International Journal of Cancer, May 13, 2013 Clinical Article

94 Modelling the benefits of early diagnosis of pancreatic cancer using a biomarker signature International Journal of Cancer, May 13, 2013 Clinical Article

95 The genomic landscape of chronic lymphocytic leukemia: clinical implications Full Text BMC Medicine, May 13, 2013

96 Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro Full Text Lipids in Health and Disease, May 13, 2013 Review Article

97 Plk1-dependent microtubule dynamics promotes androgen receptor signaling in prostate cancer The Prostate, May 13, 2013 Clinical Article

98 Immunohistochemical expression of ERG in the molecular epidemiology of fatal prostate cancer study The Prostate, May 13, 2013 Clinical Article

99 Anaemia and cognitive performances in the elderly: a systematic review European Journal of Neurology, May 13, 2013 Evidence Based Medicine Review Article

100 Expression of VEGF and Semaphorin Genes Define Subgroups of Triple Negative Breast Cancer PLOS ONE, May 13, 2013 Review Article

50 available pages First Previous 5 6 7 8 9 10 11 12 13 14 Next Last

Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 New Perspectives of Curcumin in Cancer Prevention Cancer Prevention Research, April 17, 2013 Review Article

2 Leukaemia update. Part 1: diagnosis and management British Medical Journal, April 9, 2013 Review Article

3 Treatment of Iron-deficiency Anemia in Patients with Subclinical Hypothyroidism American Journal of Medicine, April 18, 2013

4 Statin use and risk of prostate cancer and high-grade prostate cancer: results from the REDUCE study Prostate Cancer & Prostatic Diseases, April 11, 2013

5 Enalapril And Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients with Malignant Hemopathies. The OVERCOME Trial JACC - Journal of the American College of Cardiology, April 12, 2013

6 Iron deficiency in chronic heart failure: An international pooled analysis American Heart Journal, April 1, 2013

7 The changing paradigm of CLL management European Journal of Internal Medicine , April 17, 2013 Review Article

8 Efficacy and safety of dabigatran etexilate and warfarin in real world patients with atrial fibrillation: A prospective nationwide cohort study JACC - Journal of the American College of Cardiology, April 15, 2013

9 Strategy for detection of prostate cancer based on relation between prostate specific antigen at age 40-55 and long term risk of metastasis: case-control study British Medical Journal, April 23, 2013

10 The role of Helicobacter pylori infection in hematological disorders European Journal of Internal Medicine , March 29, 2013 Review Article

11 Red flags to screen for malignancy in patients with low-back pain Cochrane Reviews, March 8, 2013

12 Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013 Mayo Clinic Proceedings, April 9, 2013 Free full text Clinical Guideline

13 Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality European Urology, March 27, 2013 Free full text

14 Cervical cancer screening: What’s new and what’s coming? Cleveland Clinic Journal of Medicine, March 19, 2013

15 Effective elimination of dabigatran by haemodialysis Thrombosis and Haemostasis, April 12, 2013

16 Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly The Lancet Oncology, May 10, 2012

17 The impact of coffee on health Maturitas, February 26, 2013

18 MicroRNA Profiling Can Classify Acute Leukemias of Ambiguous Lineage as Either Acute Myeloid Leukemia or Acute Lymphoid Leukemia Clinical Cancer Research, April 9, 2013

19 Ideal Cardiovascular Health Is Inversely Associated With Incident Cancer Circulation, March 27, 2013

20 Thromboprophylaxis for trauma patients Cochrane Reviews, April 1, 2013 Review Article

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Hematology/Oncology News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine