Internal Medicine - Hematology/Oncology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (52) Full Text Articles (1465) Focus on Neurologic Disorders

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

581 Combination of fludarabine, amsacrine, and cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with high-risk acute myeloid leukemia Annals of Hematology, June 3, 2013 Clinical Article

582 Suppression of ser/thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death. Molecular Cancer Research, June 3, 2013 Clinical Article

583 Immunogenicity of dendritic cells pulsed with MAGE3, Survivin and B-cell maturation antigen mRNA for vaccination of multiple myeloma patients Cancer Immunology, Immunotherapy, June 3, 2013 Clinical Article

584 Detection of EGFR T790M mutation in plasma DNA from patients refractory to EGFR tyrosine kinase inhibitor Cancer Science, June 3, 2013 Clinical Article

585 Prediction of response to neoadjuvant chemotherapy in breast cancer patients by circulating apoptotic biomarkers nucleosomes, DNAse, cytokeratin-18 fragments and survivin Cancer Letters, June 3, 2013 Clinical Article

586 STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion Cancer Letters, June 3, 2013 Clinical Article

587 To Freeze Or Not To Freeze Peripheral Blood Stem Cells Prior To Allogeneic Transplantation From Sibling Matched Related Donors European Journal of Haematology, June 3, 2013 Clinical Article

588 Transfusion and hematologic variables after fibrinogen or platelet transfusion in valve replacement surgery: preliminary data of purified lyophilized human fibrinogen concentrate versus conventional transfusion Transfusion, June 3, 2013 Clinical Article

589 Successful short-term cryopreservation of volume-reduced cord blood units in a cryogenic mechanical freezer: effects on cell recovery, viability, and clonogenic potential Transfusion, June 3, 2013 Clinical Article

590 Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors Molecular Carcinogenesis, June 3, 2013 Clinical Article

591 A potentially neuroprotective role for erythropoietin with paclitaxel treatment in ovarian cancer patients: a prospective phase II GINECO trial Supportive Care in Cancer, June 3, 2013 Clinical Article

592 Association of vascular endothelial growth factor (VEGF) gene polymorphism and increased serum VEGF concentration with pancreatic adenocarcinoma Pancreatology, June 3, 2013 Review Article

593 Morbidity after transperineal prostate biopsy in 3000 patients undergoing 12 vs 18 vs more than 24 needle cores Urology, June 3, 2013 Clinical Article

594 Automated preparation of whole blood-derived platelets suspended in two different platelet additive solutions and stored for 7 days Transfusion, June 3, 2013 Clinical Article

595 Minimal clinically important differences in the brief pain inventory in patients with bone metastases Supportive Care in Cancer, June 3, 2013 Clinical Article

596 Relationships between hepatitis B infection status and liver dysfunction after chemotherapy of lung cancer patients in mainland China Supportive Care in Cancer, June 3, 2013 Clinical Article

597 Breast cancer screening conflicting guidelines and medicolegal risk breast cancer screening JAMA, May 31, 2013 Clinical Guideline Clinical Article

598 Salvage-targeted kidney cancer therapy in patients progressing on high-dose interleukin-2 immunotherapy: the UCLA experience Full Text The Cancer Journal, May 31, 2013 Clinical Article

599 Quality of care indicators and their related outcomes: A population-based study in prostate cancer patients treated with radiotherapy Radiotherapy & Oncology, May 31, 2013 Clinical Article

600 Elasticity as a biomarker for prostate cancer: A systematic review BJU International, May 31, 2013 Evidence Based Medicine Review Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Med Articles

Last month's top read Top Articles of 2012

1 The relationship between nutrition and prostate cancer: is more always better? European Urology, May 3, 2013 Free full text Review Article

2 The New Oral Anticoagulants in Clinical Practice Mayo Clinic Proceedings, May 13, 2013

3 Dietary fiber and the risk of precancerous lesions and cancer of the esophagus: a systematic review and meta-analysis Nutrition Reviews, April 30, 2013 Evidence Based Medicine Review Article

4 Obesity and prostate cancer: weighing the evidence European Urology, May 3, 2013 Free full text Review Article

5 Strategy for detection of prostate cancer based on relation between prostate specific antigen at age 40-55 and long term risk of metastasis: case-control study British Medical Journal, April 23, 2013

6 Egg consumption and risk of bladder cancer: a meta-analysis Nutrition and Cancer, May 17, 2013

7 Risk of a Second Primary Cancer after Non-melanoma Skin Cancer in White Men and Women: A Prospective Cohort Study PLoS Medicine, May 6, 2013 Free full text

8 IRON-HF study: A randomized trial to assess the effects of iron in heart failure patients with anemia International Journal of Cardiology, May 20, 2013

9 Ultrasonography in prostate cancer: current roles and potential applications in radiorecurrent disease World Journal of Urology, May 7, 2013

10 Coffee and caffeine intake and breast cancer risk: An updated dose-response meta-analysis of 37 published studies Gynecologic Oncology, May 10, 2013 Evidence Based Medicine

11 Guidelines on Management of Prostate Cancer Annals, Academy of Medicine, Singapore, May 8, 2013 Free full text Clinical Guideline

12 Results of initial low-dose computed tomographic screening for lung cancer New England Journal of Medicine, May 24, 2013 Evidence Based Medicine

13 Leukaemia update. Part 1: diagnosis and management British Medical Journal, April 9, 2013 Review Article

14 New Perspectives of Curcumin in Cancer Prevention Cancer Prevention Research, April 17, 2013 Review Article

15 Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage BMC Genomics, May 28, 2013 Free full text

16 Breast cancer detection and survival among women with cosmetic breast implants: systematic review and meta-analysis of observational studies British Medical Journal, May 8, 2013 Evidence Based Medicine

17 A low dietary ratio of omega-6 to omega-3 fatty acids may delay progression of prostate cancer Nutrition and Cancer, May 20, 2013

18 The immunomodulatory and anticancer properties of propolis Clinical Reviews in Allergy and Immunology, May 8, 2013 Review Article

19 Pacemaker or Defibrillator Surgery without Interruption of Anticoagulation New England Journal of Medicine, May 17, 2013 Evidence Based Medicine

20 Treatment of Iron-deficiency Anemia in Patients with Subclinical Hypothyroidism American Journal of Medicine, April 18, 2013

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Hematology/Oncology News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Med Articles

Other Topics in Internal Medicine