Internal Medicine - Hematology/Oncology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (34) Full Text Articles (1465) Focus on Anxiety Disorders

Ranked, sorted, and summarized by MDLinx editors from the latest literature

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561 Recent advances and significance of intra-arterial infusion chemotherapy in non-resectable colorectal liver metastasis Full Text Journal of Gastrointestinal Oncology, May 2, 2013 Clinical Article

562 Pooled Analysis of the Prognostic and Predictive Effects of KRAS Mutation Status and KRAS Mutation Subtype in Early-Stage Resected Non-Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy Journal of Clinical Oncology, May 2, 2013 Clinical Article

563 Advancing precision medicine for prostate cancer through genomics Journal of Clinical Oncology, May 2, 2013 Review Article

564 CT With Hepatic Arterioportography as a Pretreatment Examination for Hepatocellular Carcinoma Patients: A Randomized Controlled Trial The American Journal of Gastroenterology, May 2, 2013 Clinical Article

565 Peptide receptor radionuclide therapy (PRRT) for GEP-NETs Best Practice & Research Clinical Gastroenterology , May 1, 2013 Review Article

566 Interferon α in the treatment paradigm for non–muscle-invasive bladder cancer Urologic Oncology: Seminars and Original Investigations, May 1, 2013 Clinical Article

567 Transcriptional network of androgen receptor in prostate cancer progression International Journal of Urology, May 1, 2013 Clinical Article

568 Treatment of prostate cancer with intermittent versus continuous androgen deprivation: a systematic review of randomized trials Journal of Clinical Oncology, May 1, 2013 Review Article Clinical Article

569 Next-Generation Sequencing Reveals High Concordance of Recurrent Somatic Alterations Between Primary Tumor and Metastases From Patients With Non-Small-Cell Lung Cancer Journal of Clinical Oncology, May 1, 2013 Clinical Article

570 High-Dose Cytarabine Consolidation With or Without Additional Amsacrine and Mitoxantrone in Acute Myeloid Leukemia: Results of the Prospective Randomized AML2003 Trial Journal of Clinical Oncology, May 1, 2013 Clinical Article

571 Factors Associated With Outcomes and Response to Therapy in Patients With Infiltrative Hepatocellular Carcinoma Clinical Gastroenterology and Hepatology , May 1, 2013 Clinical Article

572 Synthetic sickness or lethality points at candidate combination therapy targets in glioblastoma International Journal of Cancer, May 1, 2013 Clinical Article

573 Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells International Journal of Cancer, May 1, 2013 Clinical Article

574 Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia Cancer, May 1, 2013 Clinical Article

575 Phase 1/1b study of lonafarnib and temozolomide in patients with recurrent or temozolomide refractory glioblastoma Cancer, May 1, 2013 Clinical Article

576 Tobacco use and external beam radiation therapy for prostate cancer: Influence on biochemical control and late toxicity Cancer, May 1, 2013 Clinical Article

577 Relationship of colonoscopy-detected serrated polyps with synchronous advanced neoplasia in average-risk individuals Gastrointestinal Endoscopy, May 1, 2013 Clinical Article

578 CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer Cancer Research, May 1, 2013 Clinical Article

579 Efficacy and Safety of Busulfan-Based Conditioning Regimens for Multiple Myeloma Full Text The Oncologist, May 1, 2013 Review Article Clinical Article

580 Oncostatin M is a FIP1L1/PDGFRA-dependent mediator of cytokine production in chronic eosinophilic leukemia Allergy, May 1, 2013 Clinical Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 New Perspectives of Curcumin in Cancer Prevention Cancer Prevention Research, April 17, 2013 Review Article

2 Leukaemia update. Part 1: diagnosis and management British Medical Journal, April 9, 2013 Review Article

3 Treatment of Iron-deficiency Anemia in Patients with Subclinical Hypothyroidism American Journal of Medicine, April 18, 2013

4 Statin use and risk of prostate cancer and high-grade prostate cancer: results from the REDUCE study Prostate Cancer & Prostatic Diseases, April 11, 2013

5 Enalapril And Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients with Malignant Hemopathies. The OVERCOME Trial JACC - Journal of the American College of Cardiology, April 12, 2013

6 Iron deficiency in chronic heart failure: An international pooled analysis American Heart Journal, April 1, 2013

7 The changing paradigm of CLL management European Journal of Internal Medicine , April 17, 2013 Review Article

8 Efficacy and safety of dabigatran etexilate and warfarin in real world patients with atrial fibrillation: A prospective nationwide cohort study JACC - Journal of the American College of Cardiology, April 15, 2013

9 Strategy for detection of prostate cancer based on relation between prostate specific antigen at age 40-55 and long term risk of metastasis: case-control study British Medical Journal, April 23, 2013

10 The role of Helicobacter pylori infection in hematological disorders European Journal of Internal Medicine , March 29, 2013 Review Article

11 Red flags to screen for malignancy in patients with low-back pain Cochrane Reviews, March 8, 2013

12 Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013 Mayo Clinic Proceedings, April 9, 2013 Free full text Clinical Guideline

13 Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality European Urology, March 27, 2013 Free full text

14 Cervical cancer screening: What’s new and what’s coming? Cleveland Clinic Journal of Medicine, March 19, 2013

15 Effective elimination of dabigatran by haemodialysis Thrombosis and Haemostasis, April 12, 2013

16 Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly The Lancet Oncology, May 10, 2012

17 The impact of coffee on health Maturitas, February 26, 2013

18 MicroRNA Profiling Can Classify Acute Leukemias of Ambiguous Lineage as Either Acute Myeloid Leukemia or Acute Lymphoid Leukemia Clinical Cancer Research, April 9, 2013

19 Ideal Cardiovascular Health Is Inversely Associated With Incident Cancer Circulation, March 27, 2013

20 Thromboprophylaxis for trauma patients Cochrane Reviews, April 1, 2013 Review Article

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Hematology/Oncology News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine