Internal Medicine - Hematology/Oncology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

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481 Biopsy versus resection for the management of low-grade gliomas Cochrane Reviews, May 3, 2013 Evidence Based Medicine

482 Narrow band imaging to differentiate neoplastic and non-neoplastic colorectal polyps in real time: a meta-analysis of diagnostic operating characteristics Gut, May 3, 2013 Clinical Article

483 Urinary PGE-M: A Promising Cancer Biomarker Cancer Prevention Research, May 3, 2013 Clinical Article

484 Intratumour variation of biomarker expression by immunohistochemistry in resectable non-small cell lung cancer European Journal of Cancer, May 3, 2013 Clinical Article

485 Frameshift-derived neoantigens constitute immunotherapeutic targets for patients with microsatellite-instable haematological malignancies: Frameshift peptides for treating MSI+ blood cancers European Journal of Cancer, May 3, 2013 Clinical Article

486 Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer European Journal of Cancer, May 3, 2013 Clinical Article

487 The Increased Risk of Colon Cancer Due to Cigarette Smoking May Be Greater in Women than Men Cancer Epidemiology, Biomarkers & Prevention, May 3, 2013 Clinical Article
Exclusive Author Commentary

488 Increasing Hepatitis B Screening for Hmong Adults: Results from a Randomized Controlled Community-Based Study Cancer Epidemiology, Biomarkers & Prevention, May 3, 2013 Clinical Article

489 Geographic analysis of RKIP expression and its clinical relevance in colorectal cancer British Journal of Cancer, May 3, 2013 Clinical Article

490 Patient-reported genitourinary toxicity for long-term prostate cancer survivors treated with radiation therapy British Journal of Cancer, May 3, 2013 Clinical Article

491 Outcomes in stage I testicular seminoma: A population-based study of 9193 patients Cancer, May 3, 2013 Clinical Article

492 miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma Cancer Research, May 3, 2013 Clinical Article

493 Real-World Effectiveness of Systemic Agents Approved for Advanced Non-Small Cell Lung Cancer: A SEER-Medicare Analysis Full Text The Oncologist, May 3, 2013 Clinical Article

494 Receipt of maintenance therapy is most predictive of survival in older acute lymphoblastic leukemia patients treated with intensive induction chemotherapy regimens American Journal of Hematology, May 3, 2013 Clinical Article

495 Role of ultrasound-guided transbronchial biopsy in the diagnosis of peripheral pulmonary lesions Lung Cancer, May 3, 2013 Clinical Article

496 Risk Stratification of Opioid Misuse among Patients with Cancer Pain Using the SOAPP-SF Pain Medicine, May 3, 2013 Review Article

497 Prophylaxis of catheter-related deep vein thrombosis in cancer patients with low-dose warfarin, low molecular weight heparin, or control: a randomized, controlled, phase III study Cancer Chemotherapy and Pharmacology, May 3, 2013 Clinical Article

498 A phase II study of gemcitabine and oxaliplatin in advanced transitional cell carcinoma of the bladder Cancer Chemotherapy and Pharmacology, May 3, 2013 Clinical Article

499 Cost Effectiveness of Neoadjuvant Chemotherapy in Locally Advanced Operable Head and Neck Cancer Followed by Surgery and Postoperative Radiotherapy: A Markov Model-Based Decision Analysis Oncology, May 3, 2013 Clinical Article

500 Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells Full Text Molecular Cancer, May 3, 2013 Clinical Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 New Perspectives of Curcumin in Cancer Prevention Cancer Prevention Research, April 17, 2013 Review Article

2 Leukaemia update. Part 1: diagnosis and management British Medical Journal, April 9, 2013 Review Article

3 Treatment of Iron-deficiency Anemia in Patients with Subclinical Hypothyroidism American Journal of Medicine, April 18, 2013

4 Statin use and risk of prostate cancer and high-grade prostate cancer: results from the REDUCE study Prostate Cancer & Prostatic Diseases, April 11, 2013

5 Enalapril And Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients with Malignant Hemopathies. The OVERCOME Trial JACC - Journal of the American College of Cardiology, April 12, 2013

6 Iron deficiency in chronic heart failure: An international pooled analysis American Heart Journal, April 1, 2013

7 The changing paradigm of CLL management European Journal of Internal Medicine , April 17, 2013 Review Article

8 Efficacy and safety of dabigatran etexilate and warfarin in real world patients with atrial fibrillation: A prospective nationwide cohort study JACC - Journal of the American College of Cardiology, April 15, 2013

9 Strategy for detection of prostate cancer based on relation between prostate specific antigen at age 40-55 and long term risk of metastasis: case-control study British Medical Journal, April 23, 2013

10 The role of Helicobacter pylori infection in hematological disorders European Journal of Internal Medicine , March 29, 2013 Review Article

11 Red flags to screen for malignancy in patients with low-back pain Cochrane Reviews, March 8, 2013

12 Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013 Mayo Clinic Proceedings, April 9, 2013 Free full text Clinical Guideline

13 Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality European Urology, March 27, 2013 Free full text

14 Cervical cancer screening: What’s new and what’s coming? Cleveland Clinic Journal of Medicine, March 19, 2013

15 Effective elimination of dabigatran by haemodialysis Thrombosis and Haemostasis, April 12, 2013

16 Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly The Lancet Oncology, May 10, 2012

17 The impact of coffee on health Maturitas, February 26, 2013

18 MicroRNA Profiling Can Classify Acute Leukemias of Ambiguous Lineage as Either Acute Myeloid Leukemia or Acute Lymphoid Leukemia Clinical Cancer Research, April 9, 2013

19 Ideal Cardiovascular Health Is Inversely Associated With Incident Cancer Circulation, March 27, 2013

20 Thromboprophylaxis for trauma patients Cochrane Reviews, April 1, 2013 Review Article

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Hematology/Oncology News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine