What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.
Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.
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401 Effects of Obesity on the Impact of Short-Term Changes in Anthropometric Measurements on Coronary Heart Disease in Women Mayo Clinic Proceedings, March 29, 2013 Clinical Article
402 Sitagliptin pretreatment in diabetes patients presenting with acute coronary syndrome: results from the Acute Coronary Syndrome Israeli Survey (ACSIS) Full Text Cardiovascular Diabetology, March 29, 2013 Clinical Article
403 Is coronary CT angiography useful in diagnosing acute coronary syndromes in the Emergency Department? Internal and Emergency Medicine, March 29, 2013 Clinical Article
404 Elevated Rho-Kinase Activity as a Marker Indicating Atherosclerosis and Inflammation Burden in Polyvascular Disease Patients With Concomitant Coronary and Peripheral Arterial Disease Full Text Clinical Cardiology, March 29, 2013 Clinical Article
405 Statins of high versus low cholesterol-lowering efficacy and the development of severe renal failure Pharmacoepidemiology and Drug Safety, March 29, 2013 Clinical Article
406 Myocardial reperfusion injury: looking beyond primary PCI European Heart Journal, March 29, 2013
407 Sex disparities in risk and risk factors for ischemic heart disease in the Asia-Pacific region European Journal of Preventive Cardiology, March 29, 2013
408 Relationship Between High-Sensitivity C-Reactive Protein and Risk Factors in Patients With Peripheral Arterial Disease--A Cross-Sectional Study Angiology, March 29, 2013 Clinical Article
409 Comparison of switch to the highest dose of rosuvastatin vs. add-on nicotinic acid vs. add-on fenofibrate for mixed dyslipidaemia International Journal of Clinical Practice, March 29, 2013 Clinical Article
410 Carotid Artery Plaque and Progression of Coronary Artery Calcium: The Multi-Ethnic Study of Atherosclerosis Journal of the American Society of Echocardiography, March 29, 2013 Clinical Article
411 Metabolomic signatures in lipid-loaded HepaRGs reveal pathways involved in steatotic progression Obesity, March 29, 2013 Review Article
412 Transfer of lipids to High-Density Lipoprotein (HDL) is diminished in patients with familial hypercholesterolemia Metabolism, March 29, 2013 Review Article
413 Spousal support in a behavior change intervention for cholesterol management Patient Education and Counselling, March 29, 2013 Review Article Clinical Article
414 Bifurcation stenting in patients with ST-Segment elevation myocardial infarction Catheterization and Cardiovascular Interventions, March 28, 2013 Clinical Article
415 Effect of Radial Versus Femoral Access on Radiation Dose and the Importance of Procedural Volume A Substudy of the Multicenter Randomized RIVAL Trial Full Text JACC Cardiovascular Interventions, March 28, 2013 Clinical Article
416 Long-term outcomes of fractional flow reserve-guided vs. angiography-guided percutaneous coronary intervention in contemporary practice European Heart Journal, March 28, 2013 Clinical Article
417 Strategies of Clopidogrel Load and Atorvastatin Reload to Prevent Ischemic Cerebral Events in Patients Undergoing Protected Carotid Stenting Results of the Randomized ARMYDA-9 CAROTID (Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting) Study Full Text JACC - Journal of the American College of Cardiology, March 28, 2013 Clinical Article
418 Dose-comparative effects of different statins on serum lipid levels: a network meta-analysis of 256,827 individuals in 181 randomized controlled trials European Journal of Preventive Cardiology, March 28, 2013 Evidence Based Medicine Review Article
419 Coronary calcium scanning independently detects coronary artery disease in asymptomatic firefighters: A prospective study Journal of Cardiovascular Computed Tomography, March 28, 2013 Clinical Article
420 Antibodies to citrullinated peptides and risk of coronary heart disease Atherosclerosis, March 28, 2013 Clinical Article
Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).
Read the article summaryResearchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.
Read the article summaryResearchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.
Read the article summary1 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013
2 Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives European Heart Journal, April 11, 2013
3 Renin-angiotensin system inhibitors for prevention of recurrent atrial fibrillation: a meta-analysis International Journal of Clinical Practice, April 9, 2013 Evidence Based Medicine Review Article
4 L-Carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis Mayo Clinic Proceedings, April 19, 2013 Evidence Based Medicine Review Article
5 Six-Minute Walk Test: An Effective and Necessary Tool in Modern Cardiac Rehabilitation The Hellenic Journal of Cardiology, April 16, 2013 Free full text Review Article
6 Mortality and Morbidity During and After Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Hypertension, April 19, 2013
7 Effect of seven-day atorvastatin pretreatment on the incidence of periprocedural myocardial infarction following percutaneous coronary intervention in patients receiving long-term statin therapy. A randomized study International Journal of Cardiology, April 19, 2013
8 The Importance of 24-Hour Ambulatory Blood Pressure Monitoring in Patients at Risk of Cardiovascular Events High Blood Pressure & Cardiovascular Prevention, April 16, 2013
9 Is Overweight a Risk of Early Atherosclerosis in Childhood? Angiology, February 28, 2013
10 Cholesterol and prostate cancer Current Opinion in Pharmacology , February 4, 2013
11
Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Non-Linear Association
Journal of Clinical Endocrinology and Metabolism, March 27, 2013
Exclusive Author Commentary
12 Omega-3 fatty acids: Benefits for cardio-cerebro-vascular diseases Atherosclerosis, December 5, 2012
13 Oxygen therapy in acute coronary syndrome: are the benefits worth the risk? European Heart Journal, April 8, 2013 Review Article
14 Primary Prevention of Cardiovascular Disease with a Mediterranean Diet New England Journal of Medicine, April 8, 2013 Free full text
15 Testosterone and cardiovascular risk Internal and Emergency Medicine, March 21, 2013
16 Chlorthalidone Versus Hydrochlorothiazide for the Treatment of Hypertension in Older Adults A Population-Based Cohort Study Annals of Internal Medicine, March 19, 2013
17 Cell Therapy of Peripheral Arterial Disease Circulation Research, April 29, 2013
18 Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies British Medical Journal, April 10, 2013 Free full text
19
The endocrinology of exercise
Internal and Emergency Medicine, March 27, 2013
Review Article
Exclusive Author Commentary
20 Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial The Lancet, April 18, 2013
Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more
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